Interpatient mutational spectrum of human coronavirus‐OC43 revealed by illumina sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24780
Abstract: Human coronaviruses (HCoV) are RNA viruses that cause respiratory tract infections with viral replication of limited duration. The host and viral population heterogeneity could influence clinical phenotypes. Employing long RT‐PCR with Illumina sequencing, we quantified… read more here.
Keywords: coronavirus; mutation; hcov oc43; illumina sequencing ... See more keywords
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2021.105055
Abstract: The current emergency of the novel coronavirus SARS-CoV2 urged the need for broad-spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of viruses that already challenged humanity in at least… read more here.
Keywords: hcov oc43; antipsychotic drug; sars cov2; drug ... See more keywords
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2021.02.085
Abstract: The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. We… read more here.
Keywords: hcov oc43; hcov hku1; severe course; course covid ... See more keywords
Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child
Sign Up to like & getrecommendations! Published in 2020 at "Infectious Diseases"
DOI: 10.1080/23744235.2020.1729403
Abstract: Abstract A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid… read more here.
Keywords: hcov oc43; oc43; coronavirus oc43; encephalitis associated ... See more keywords
PCR Array Profiling of Antiviral Genes in Human Embryonic Kidney Cells Expressing Human Coronavirus OC43 Structural and Accessory Proteins
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DOI: 10.1093/ofid/ofx163.728
Abstract: Background. Human coronaviruses (HCoV) OC43, 229E, NL63 and HKU1 commonly cause upper respiratory tract infections, but can also cause severe lower respiratory tract disease. Increased use of diagnostic assays for respiratory viruses has facilitated detection… read more here.
Keywords: hku1; hcov oc43; age; hcov ... See more keywords
The Stability of Model Human Coronaviruses on Textiles in the Environment and during Health Care Laundering
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DOI: 10.1128/msphere.00316-21
Abstract: Synthetic textiles such as polyester could potentially act as fomites of human coronaviruses, indicating the importance of infection control procedures during handling of contaminated textiles prior to laundering. This study provides novel evidence that human… read more here.
Keywords: laundering; human coronaviruses; hcov oc43; health care ... See more keywords
Evaluation of Environmental Stability and Disinfectant Effectiveness for Human Coronavirus OC43 on Human Skin Surface
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DOI: 10.1128/spectrum.02381-22
Abstract: This study revealed the environmental stability of HCoV-OC43 and disinfectant effectiveness against HCoV-OC43, which had not been demonstrated in previous studies. HCoV-OC43 is highly stable on the surface of human skin, with a survival time… read more here.
Keywords: disinfectant effectiveness; surface; oc43; hcov oc43 ... See more keywords
Erythromycin Estolate Is a Potent Inhibitor Against HCoV-OC43 by Directly Inactivating the Virus Particle
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.905248
Abstract: In addition to antibacterial effects, macrolide antibiotics exhibit other extensive pharmacological effects, such as anti-inflammatory and antiviral activities. Erythromycin estolate, one of the macrolide antibiotics, was previously investigated to effectively inhibit infections of various flaviviruses… read more here.
Keywords: erythromycin estolate; oc43 infection; virus; hcov oc43 ... See more keywords
Pre-existing anti-HCoV-OC43 immunity influences the durability and cross-reactivity of humoral response to SARS-CoV-2 vaccination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.978440
Abstract: Purpose This study was conducted in order to properly understand whether prior seasonal human coronavirus (HCoV) immunity could impact the potential cross-reactivity of humoral responses induced by SARS-CoV-2 vaccine, thereby devising universal coronavirus vaccines for… read more here.
Keywords: pre existing; vaccination; hcov; sars cov ... See more keywords
Fatal Pneumonia Associated With a Novel Genotype of Human Coronavirus OC43
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.795449
Abstract: Since its first discovery in 1967, human coronavirus OC43 (HCoV-OC43) has been associated with mild self-limiting upper respiratory infections worldwide. Fatal primary pneumonia due to HCoV-OC43 is not frequently described. This study describes a case… read more here.
Keywords: pneumonia; human coronavirus; genotype; oc43 ... See more keywords
A Mouse-Adapted Model of HCoV-OC43 and Its Usage to the Evaluation of Antiviral Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.845269
Abstract: The human coronavirus OC43 (HCoV-OC43) is one of the most common causes of common cold but can lead to fatal pneumonia in children and elderly. However, the available animal models of HCoV-OC43 did not show… read more here.
Keywords: adapted model; model hcov; mouse adapted; hcov oc43 ... See more keywords