LC-MS/MS methods to quantify HCP002 in human plasma and urine: applications in a pharmacokinetic study.
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DOI: 10.4155/bio-2021-0246
Abstract: Aim: HCP002, a phosphate-modified derivative of voriconazole, can improve solubility without using the nephrotoxic solubilizer, sulfobutylether-β-cyclodextrin. To study pharmacokinetics in humans, LC-MS/MS methods to quantify HCP002 in human plasma and urine were developed and validated.… read more here.
Keywords: plasma urine; hcp002 human; plasma; methods quantify ... See more keywords