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   Articles with "hcpt" as a keyword



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AMPK‐mTOR‐ULK1 axis activation‐dependent autophagy promotes hydroxycamptothecin‐induced apoptosis in human bladder cancer cells

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.29307

Abstract: 10‐hydroxycamptothecin (HCPT), a natural plant extract, exerts anticancer capacity. HCPT has been reported to induce apoptosis and autophagy in human cancer cells. The interaction between autophagy and apoptosis induced by HCPT and the molecular mechanism… read more here.

Keywords: bladder cancer; hcpt; cancer cells; apoptosis ... See more keywords
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Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

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recommendations! Published in 2020 at "Science China Materials"

DOI: 10.1007/s40843-019-1260-y

Abstract: Developing intrinsically mitochondria-targetable nanosystems for subcellular structure-oriented precise cancer therapy is highly desirable. Here, we conjugate the cluster determinant 44 (CD44)-targetable hyaluronic acid (HA) with cholesterol-poly(ethylene glycol) 2k -NH 2 and mitochondria-acting IR825-NH 2 (a… read more here.

Keywords: chol; hcpt; chemo photothermal; therapy ... See more keywords
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Melatonin Reverses 10-Hydroxycamptothecin-Induced Apoptosis and Autophagy in Mouse Oocyte

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recommendations! Published in 2020 at "Reproductive Sciences"

DOI: 10.1007/s43032-020-00359-4

Abstract: 10-Hydroxycamptothecin (HCPT) is a widely used anticancer drug that induces cytotoxicity by triggering the cell apoptotic pathway. Studies have shown that HCPT has harmful effects on normal cells, but whether HCPT affects the development of… read more here.

Keywords: apoptosis; hcpt; induced apoptosis; group ... See more keywords
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White light emission from single natural molecules: Solvatochromic properties of 10-hydroxycamptothecin

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recommendations! Published in 2020 at "Dyes and Pigments"

DOI: 10.1016/j.dyepig.2020.108533

Abstract: Abstract With the development of display systems, artificial lighting, and fluorescent sensor, white light emission (WLE) materials have received great attention in recent years. Various organic and inorganic compounds have been synthesized to generate WLE.… read more here.

Keywords: single natural; wle; light emission; hcpt ... See more keywords
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Effect of alkyl chain on cellular uptake and antitumor activity of hydroxycamptothecin nanoparticles based on amphiphilic linear molecules

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recommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2018.08.043

Abstract: ABSTRACT Drug‐loaded nanoparticles utilizing amphiphilic molecules as nanocarriers were developed broadly for nanoscale drug delivery system. Linear amphiphilic molecule (PEG45C18) based on PEG and alkyl chain was designed and synthesized. To study the influence of… read more here.

Keywords: alkyl; hcpt; antitumor activity; antitumor ... See more keywords
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Nanocochleates as the Potential Delivery Systems for Oral Antitumor of Hydroxycamptothecin.

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recommendations! Published in 2018 at "Journal of biomedical nanotechnology"

DOI: 10.1166/jbn.2018.2572

Abstract: It remains a major challenge to improve the oral antitumor efficacy of hydroxycamptothecin (HCPT). The aim of this study was to develop the oral HCPT formulation via nanocochleates technology. After HCPT was incorporated into calcium… read more here.

Keywords: hcpt; delivery; loaded nanocochleates; hcpt loaded ... See more keywords

10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy

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recommendations! Published in 2017 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s134005

Abstract: In this study, polyethylene glycol (PEG)ylated 10-hydroxycamptothecin (mPEG1000-HCPT) was synthesized and used as a stabilizer to prepare 10-hydroxycamptothecin (HCPT) nanosuspensions for their in vitro and in vivo antitumor investigation. The resultant HCPT nanosuspensions (HCPT-NSps) had… read more here.

Keywords: hcpt nanosuspensions; antitumor efficacy; mpeg1000 hcpt; hcpt ... See more keywords
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Mitochondrial-Targeted Triphenylphosphonium–Hydroxycamptothecin Conjugate and Its Nano-Formulations for Breast Cancer Therapy: In Vitro and In Vivo Investigation

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recommendations! Published in 2023 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics15020388

Abstract: Mitochondria are involved in various stages of cancer cell diffusion and metastasis. Therefore, targeting tumor mitochondria with antineoplastic medicines to cause mitochondria to initiate apoptosis may be an effective strategy for cancer therapy. Here, in… read more here.

Keywords: conjugate; hcpt; cancer therapy; tumor ... See more keywords

Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing epidural fibrosis

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recommendations! Published in 2017 at "PeerJ"

DOI: 10.7717/peerj.2858

Abstract: The fibrosis that develops following laminectomy or discectomy often causes serious complications, and the proliferation of fibroblasts is thought to be the major cause of epidural fibrosis. 10-Hydroxycamptothecin (HCPT) has been proven to be efficient… read more here.

Keywords: fibrosis; epidural fibrosis; hcpt; reducing epidural ... See more keywords