Intracellular Nanoparticle Formation and Hydroxychloroquine Release for Autophagy‐Inhibited Mild‐Temperature Photothermal Therapy for Tumors
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DOI: 10.1002/adfm.202102832
Abstract: Mild‐temperature photothermal therapy (PTT) of tumors has been intensively explored and adopted in preclinical/clinical trials in recent years. Nevertheless, tumor thermoresistance significantly compromises the therapeutic efficacy of mild‐temperature PTT, and therefore, the extra addition of… read more here.
Keywords: cyp hcq; hcq; nanoparticle formation; mild temperature ... See more keywords
Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase
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DOI: 10.1007/s00228-021-03133-w
Abstract: Purpose To analyze the cases of torsade de pointes (TdP) and related symptoms reported in association with chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZT) to the World Health Organization (WHO) global database of individual case… read more here.
Keywords: hcq; ror; hcq azt; torsade pointes ... See more keywords
Optical coherence tomography angiography for screening of hydroxychloroquine-induced retinal alterations
Sign Up to like & getrecommendations! Published in 2018 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-018-4117-3
Abstract: Background/aimsThe purpose of the study was to evaluate the retinal and choroidal changes via optical coherence tomography angiography (OCTA) in patients who received hydroxychloroquine (HCQ).MethodsSixty eyes of 60 female patients who received HCQ were included… read more here.
Keywords: risk group; risk; induced retinal; hcq ... See more keywords
The effect of hydroxychloroquine on platelet activation in model experiments
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02325-y
Abstract: Hydroxychloroquine (HCQ) is an antimalarial agent with pleiotropic effects and now represents a cornerstone in the management of patients with autoimmune conditions. While clinical series suggest anti-thrombotic properties, the way in which HCQ exerts this… read more here.
Keywords: effect; expression cd40l; hcq; platelet activation ... See more keywords
Letter About: Risk Factors for Mortality in Patients with COVID-19 in New York City
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DOI: 10.1007/s11606-020-06369-x
Abstract: Dear Editor, We read with interest the study by Mikami et al. about the association of hydroxychloroquine (HCQ) with mortality in 3708 patients hospitalized with COVID-19. The authors reported adjusted HRs from a Cox regression… read more here.
Keywords: risk; hcq; hcq associated; treatment ... See more keywords
Long-term use of hydroxychloroquine reduces antiphospholipid antibodies levels in patients with primary antiphospholipid syndrome
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DOI: 10.1007/s12026-016-8812-z
Abstract: Hydroxychloroquine (HCQ) was suggested to play a role in lowering antiphospholipid antibody titers and preventing thrombotic recurrences in patients with systemic lupus erythematosus, but few data are available in patients with primary antiphospholipid syndrome (PAPS).… read more here.
Keywords: primary antiphospholipid; antiphospholipid syndrome; hcq; exposed patients ... See more keywords
Prévalence des effets indésirables de l’hydroxychloroquine (Plaquenil®) dans une population dermatologique : étude rétrospective sur 102 patients
Sign Up to like & getrecommendations! Published in 2018 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2018.03.168
Abstract: Resume But L’objectif de cette etude etait d’etudier la prevalence des effets indesirables (EI) et celle de l’arret de l’hydroxychloroquine (HCQ) pour EI dans une population issue d’un recrutement dermatologique. Patients et methodes Il s’agissait… read more here.
Keywords: des effets; hcq; une population; 102 patients ... See more keywords
P-106 COVID-19 PRESENTATION AND OUTCOMES IN 33 PATIENTS WITH AUTOIMMUNE HEPATITIS
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DOI: 10.1016/j.aohep.2021.100466
Abstract: Background and Aims Clinical course of Covid-19 is not yet established in autoimmune hepatitis (AIH). About 25% of our 400 AIH-outpatients from various states in Brazil are using hydrochloroquine (HCQ) for maintenance or treatment with… read more here.
Keywords: 106 covid; covid presentation; hcq; outcomes patients ... See more keywords
Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.04.058
Abstract: Renal fibrosis is the ultimate presentation of chronic kidney disease, which progresses to end-stage renal disease. Hydroxychloroquine (HCQ) has been adapted for the treatment of autoimmune diseases; however, the potential mechanism underlying the role of… read more here.
Keywords: hcq; fibrosis; renal fibrosis; akt signaling ... See more keywords
Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by blocking TLR9 in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108461
Abstract: Hepatic ischemia/reperfusion (I/R) injury may arise after partial hepatectomy and liver transplantation. Neutrophil extracellular traps (NETs) were involved in hepatic I/R injury. This study tested the hypothesis that blocking NETs formation could be a potential… read more here.
Keywords: blocking tlr9; hcq; formation; injury ... See more keywords
Withania somnifera as a safer option to hydroxychloroquine in the chemoprophylaxis of COVID-19: Results of interim analysis
Sign Up to like & getrecommendations! Published in 2021 at "Complementary Therapies in Medicine"
DOI: 10.1016/j.ctim.2021.102768
Abstract: Objectives To study the efficacy and safety of Withania somnifera (WS) in the prophylaxis against COVID-19 in high risk health care workers (HCW) in comparison to hydroxychloroquine (HCQ). To evaluate general physical and mental health… read more here.
Keywords: withania somnifera; hcq; safer option; interim analysis ... See more keywords