Hypocretins (orexins): The ultimate translational neuropeptides
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DOI: 10.1111/joim.13406
Abstract: The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively in the lateral hypothalamus. They act on two specific receptors that are widely distributed across the brain and involved in a myriad of… read more here.
Keywords: hcrt; orexins ultimate; hcrt system; hypocretins orexins ... See more keywords
Hyperexcitable arousal circuits drive sleep instability during aging
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DOI: 10.1126/science.abh3021
Abstract: Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt neurons exhibited more frequent neuronal activity epochs driving… read more here.
Keywords: kcnq2; sleep fragmentation; hcrt; hcrt neurons ... See more keywords
Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss
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DOI: 10.1371/journal.pone.0178573
Abstract: The loss of specific neuronal phenotypes, as determined by immunohistochemistry, has become a powerful tool for identifying the nature and cause of neurological diseases. Here we show that the number of neurons identified and quantified… read more here.
Keywords: hypocretin orexin; hcrt; number; size ... See more keywords
Plasticity of the hypocretinergic/orexinergic system after a chronic treatment with suvorexant in rats. Role of the hypocretinergic/orexinergic receptor 1 as an autoreceptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1013182
Abstract: The hypothalamic hypocretinergic/orexinergic (Hcrt/Ox) system is involved in many physiological and pathophysiological processes. Malfunction of Hcrt/Ox transmission results in narcolepsy, a sleep disease caused in humans by progressive neurodegeneration of hypothalamic neurons containing Hcrt/Ox. To… read more here.
Keywords: hcrt1 oxa; hypocretinergic orexinergic; hcrt; hcrt system ... See more keywords