Identification of discrete, intermingled hypocretin neuronal populations
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24490
Abstract: Neurons in the lateral hypothalamic area that express hypocretin (Hcrt) neuropeptides help regulate many behaviors including wakefulness and reward seeking. These neurons project throughout the brain, including to neural populations that regulate wakefulness, such as… read more here.
Keywords: identification discrete; hcrt neurons; intermingled hypocretin; hypocretin neuronal ... See more keywords
Hyperexcitable arousal circuits drive sleep instability during aging
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abh3021
Abstract: Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt neurons exhibited more frequent neuronal activity epochs driving… read more here.
Keywords: kcnq2; sleep fragmentation; hcrt; hcrt neurons ... See more keywords