Relationship between anticancer sensitivities and cellular respiration properties in 5-fluorouracil-resistant HCT116 human colorectal cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13611
Abstract: 5‐Fluorouracil (5‐FU) is widely used for colorectal cancer (CRC) treatment; however, continuous treatment of CRC cells with 5‐FU can result in acquired resistance, and the underlying mechanism of 5‐FU resistance remains unclear. We previously established… read more here.
Keywords: cellular respiration; hct116; low glucose; colorectal cancer ... See more keywords
Supervillin‐Mediated ZO‐1 Downregulation Facilitates Migration of Cisplatin‐Resistant HCT116 Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30699
Abstract: Supervillin (SVIL), the biggest member of the villin/gelsolin superfamily, has recently been reported to promote the metastasis of hepatocellular carcinoma by stimulating epithelial‐mesenchymal transition (EMT). However, little is known about the roles of SVIL in… read more here.
Keywords: colorectal cancer; cancer; hct116; cancer cells ... See more keywords
Square planar Au(III), Pt(II) and Cu(II) complexes with quinoline-substituted 2,2':6',2″-terpyridine ligands: From in vitro to in vivo biological properties.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113404
Abstract: Cancer is the second leading cause of death worldwide. Cisplatin has challenged cancer treatment; however, resistance and side effects hamper its use. New agents displaying improved activity and more reduced side effects relative to cisplatin… read more here.
Keywords: dna; quinoline substituted; substituted terpyridine; complexes quinoline ... See more keywords
Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.02.006
Abstract: Programmed cell death protein 1 (PD-1) acts on PD-1 ligands (PD-L1 and PD-L2) to suppress activation of cytotoxic T lymphocytes. Interleukin-17 (IL-17) and tumor necrosis factor-α (TNF-α) are co-expressed by T helper 17 (TH17) cells… read more here.
Keywords: protein expression; tnf; expression; cancer ... See more keywords
The involvement of ROS generation on Epoxiconazole-induced toxicity in HCT116 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2018.03.014
Abstract: Abstract Triazole fungicides are the most efficient class of pesticides and have been in rapid development since the 1970s, receiving worldwide recognition. Epoxiconazole is a systemic fungicide belonging to the most widely used members of… read more here.
Keywords: involvement ros; generation; ros generation; generation epoxiconazole ... See more keywords
Development of the 5-Nitrosalicaldehyde Arylhydrazones as Anticancer (MCF-7 and HCT116) Agents Targeting Inhibition of VEGFR-2 and Cytokines (IL-6 and TNF-α)
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c07719
Abstract: A pseudoring replacement strategy has been employed to develop the 3-halogeno-substituted 5-nitrosalicylaldehyde arylhydrazones as potential antibreast (MCF-7) and anticolorectal (HCT116) cancer agents. The mechanism of action of the test compounds was investigated through cell cycle… read more here.
Keywords: development nitrosalicaldehyde; hct116; inhibition; vegfr ... See more keywords
Novel fluorinated thiazolidin-4-one derivatives: synthesis and anti-cancer potential against HepG2 and HCT116 cell lines
Sign Up to like & getrecommendations! Published in 2024 at "Australian Journal of Chemistry"
DOI: 10.1071/ch23123
Abstract: A novel synthetic route has been designed to introduce fluorine functionality into a series of compounds containing thiazolidin-4-one rings. These compounds were synthesised from various aniline derivatives using a two-step approach: an addition reaction of… read more here.
Keywords: cancer; hct116; cell lines; novel fluorinated ... See more keywords
Evodiamine inhibits vasculogenic mimicry in HCT116 cells by suppressing hypoxia-inducible factor 1-alpha-mediated angiogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001030
Abstract: Evodiamine (Evo), a quinazoline alkaloid and one of the most typical polycyclic heterocycles, is mainly isolated from Evodia rugulosa. Vasculogenic mimicry (VM) is a newly identified way of angiogenesis during tumor neovascularization, which is prevalent… read more here.
Keywords: hypoxia inducible; hct116; vasculogenic mimicry; factor alpha ... See more keywords
Tumoral Malignancy Decreases Coupled with Higher ROS and Lipid Peroxidation in HCT116 Colon Cancer Cells upon Loss of PRDX6
Sign Up to like & getrecommendations! Published in 2024 at "Antioxidants"
DOI: 10.3390/antiox13070881
Abstract: Peroxiredoxin 6 (PRDX6) is an atypical member of the peroxiredoxin family that presents not only peroxidase but also phospholipase A2 and lysophosphatidylcholine acyl transferase activities able to act on lipid hydroperoxides of cell membranes. It… read more here.
Keywords: cancer; hct116; cancer cells; lipid peroxidation ... See more keywords
MHY2245, a Sirtuin Inhibitor, Induces Cell Cycle Arrest and Apoptosis in HCT116 Human Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031590
Abstract: Sirtuins (SIRTs), which are nicotinamide adenine dinucleotide-dependent class III histone deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic SIRT inhibitor, is known to exhibit antitumor effects, its mechanism of action is not… read more here.
Keywords: cancer; cycle arrest; cycle; hct116 ... See more keywords
Comparative Analyses of Fucoidans from South African Brown Seaweeds That Inhibit Adhesion, Migration, and Long-Term Survival of Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Marine Drugs"
DOI: 10.3390/md21040203
Abstract: Human colorectal cancer (CRC) is a recurrent, deadly malignant tumour with a high incidence. The incidence of CRC is of increasing alarm in highly developed countries, as well as in middle to low-income countries, posing… read more here.
Keywords: cancer; fucoidans south; hct116; migration ... See more keywords