Relation between structures of naphthalenylchalcone derivatives and their cytotoxic effects on HCT116 human colon cancer cells
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DOI: 10.1007/s13765-018-0356-6
Abstract: To find potent chemotherapeutic agents, cytotoxic effects of 42 synthetic chalcone derivatives bearing naphthyl groups on HCT116 human colon cancer cell lines were tested using the clonogenic long-term survival assay. The relationships between their half-maximal… read more here.
Keywords: cytotoxic effects; hct116 human; human colon; colon cancer ... See more keywords
In Silico HCT116 Human Colon Cancer Cell-Based Models En Route to the Discovery of Lead-Like Anticancer Drugs
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DOI: 10.3390/biom8030056
Abstract: To discover new inhibitors against the human colon carcinoma HCT116 cell line, two quantitative structure–activity relationship (QSAR) studies using molecular and nuclear magnetic resonance (NMR) descriptors were developed through exploration of machine learning techniques and… read more here.
Keywords: silico hct116; hct116 human; colon; human colon ... See more keywords