Prevalence of Hepatitis C Virus Infection in US States and the District of Columbia, 2013 to 2016
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DOI: 10.1001/jamanetworkopen.2018.6371
Abstract: Key Points Question During 2013 to 2016, what proportion of adults were living with hepatitis C virus (HCV) infection in each US state? Findings In this survey study, US national HCV prevalence during 2013 to… read more here.
Keywords: 2013 2016; hepatitis virus; hcv; prevalence ... See more keywords
Pancreatic Ductal Adenocarcinoma After Hepatitis C Infection
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DOI: 10.1001/jamanetworkopen.2025.43701
Abstract: Key Points Question Is there an association between chronic hepatitis C virus (HCV) infection and pancreatic cancer, independent of other risk factors? Findings In this cohort study of 6.3 million veterans, individuals with chronic HCV… read more here.
Keywords: risk; hepatitis; hcv; infection ... See more keywords
Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein‐Protein Interaction Identification in Glycoengineered CHO Cells
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DOI: 10.1002/biot.70112
Abstract: Hepatitis C Virus (HCV) is a pervasive bloodborne virus and the leading cause of chronic liver disease and cancer. Thus, the development of an HCV vaccine is of great importance. Prior work has developed candidate… read more here.
Keywords: cho cells; protein; hcv; protein protein ... See more keywords
Transplanting hepatitis C virus–positive livers into hepatitis C virus–negative patients with preemptive antiviral treatment: A modeling study
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29723
Abstract: Under current guidelines, hepatitis C virus (HCV)‐positive livers are not transplanted into HCV‐negative recipients because of adverse posttransplant outcomes associated with allograft HCV infection. However, HCV can now be cured post‐LT (liver transplant) using direct‐acting… read more here.
Keywords: negative patients; hcv; hcv negative; hcv positive ... See more keywords
Proton pump inhibitors, Enterococcus, and the liver, oh my!
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DOI: 10.1002/hep.29822
Abstract: humans. The need for a new model of HCV infection is acute. DAA therapy will likely have limited impact on HCV disease burden in the foreseeable future. Most HCV infections are undiagnosed and virus transmission… read more here.
Keywords: pump inhibitors; hcv; infection; enterococcus liver ... See more keywords
Direct acting antivirals for patients without advanced liver disease: All for treatment and treatment for all?
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29873
Abstract: The recent advent of all-oral direct-acting antivirals (DAAs) has revolutionized the treatment of hepatitis C virus (HCV). Although access to HCV treatment has been improving in the United States (attributed to increased competition, negotiated lower… read more here.
Keywords: treatment; hcv; advanced liver; liver disease ... See more keywords
12 Weeks of a Ribavirin‐Free Sofosbuvir and Nonstructural Protein 5A Inhibitor Regimen Is Enough to Treat Recurrence of Hepatitis C After Liver Transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29918
Abstract: Sofosbuvir (SOF) combined with nonstructural protein 5A (NS5A) inhibitors has demonstrated its efficacy in treating a recurrence of hepatitis C virus (HCV) after liver transplantation (LT). However, the duration of treatment and need for ribavirin… read more here.
Keywords: inhibitor; recurrence; treatment; hcv ... See more keywords
Safety and Efficacy of Ledipasvir–Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6‐11
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DOI: 10.1002/hep.30123
Abstract: Currently, there are no interferon‐free treatments available for hepatitis C virus (HCV)–infected patients younger than 12 years. We evaluated the safety and effectiveness of the all‐oral regimen ledipasvir–sofosbuvir ± ribavirin in HCV‐infected children aged 6… read more here.
Keywords: hepatitis; hcv; safety; sofosbuvir ... See more keywords
Interferon‐Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection
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DOI: 10.1002/hep.30699
Abstract: Although adaptive immune responses against hepatitis C virus (HCV) infection have been studied in great detail, the role of innate immunity in protection against HCV infection and immune evasion is only partially understood. Interferon‐induced transmembrane… read more here.
Keywords: evasion; interferon induced; infection; hcv ... See more keywords
Responsible Inclusion of Pregnant Individuals in Eradicating HCV
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DOI: 10.1002/hep.31825
Abstract: HCV infections have increased in recent years due to injection drug use and the opioid epidemic. Simultaneously, HCV cure has become a reality, with the advent of direct‐acting antivirals (DAAs) and expansion of treatment programs.… read more here.
Keywords: research; treatment programs; hcv; pregnant individuals ... See more keywords
A pan-genotype hepatitis C virus viral vector vaccine generates T-cells and neutralizing antibodies in mice.
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DOI: 10.1002/hep.32470
Abstract: BACKGROUND & AIMS A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization (WHO) elimination targets. Neutralizing antibodies (nAb), CD4+ and CD8+ T-cells are associated with spontaneous clearance of… read more here.
Keywords: viral vector; pan genotype; hcv; neutralizing antibodies ... See more keywords