Tumour suppressor p53 inhibits hepatitis C virus replication by inducing E6AP‐mediated proteasomal degradation of the viral core protein
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14461
Abstract: The tumour suppressor p53 has been implicated in the host defence system against hepatitis C virus (HCV) infection, although the detailed mechanism remains unknown. Here, we found that p53 inhibits HCV replication by downregulating HCV… read more here.
Keywords: core; suppressor p53; p53; hcv core ... See more keywords
HCV core antigen plays an important role in the fight against HCV as an alternative to HCV‐RNA detection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23755
Abstract: To discuss the clinical significance of HCV‐cAg testing in the diagnosis, activity determination, and monitoring of therapeutic effectiveness of HCV infection and its advantages compared with HCV‐RNA and anti‐HCV antibodies detection. read more here.
Keywords: core antigen; antigen plays; hcv; hcv rna ... See more keywords
Detection of Antigen-Specific CD8+ T Cells in the Livers of HCV Core Transgenic Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8976-8_31
Abstract: Hepatitis C virus-mediated immune suppression is an underlying feature leading to the establishment of viral persistence and chronic infection. In particular, HCV core protein has been shown to exhibit significant immunosuppressive activity of T cells… read more here.
Keywords: specific cd8; antigen specific; transgenic mice; core transgenic ... See more keywords
The immunogenicity in mice of hepatitis C virus core protein delivered as DNA is modulated by its capacity to promote ROS production and activate Nrf2/ARE pathway
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.253
Abstract: Hepatitis C virus (HCV) core protein is an attractive target for HCV vaccine, however little progress was achieved in trials. We aimed to delineate the factors restricting immunogenicity of HCV core, and to improve its… read more here.
Keywords: protein; core protein; ros production; hcv core ... See more keywords
Hepatitis C virus core protein reduces CD8+ T‐cell proliferation, perforin production and degranulation but increases STAT5 activation
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1111/imm.12882
Abstract: Clearance of hepatitis C virus (HCV) is dependent on an effective virus‐specific CD8+ T‐cell response, which is dysfunctional in chronic HCV infection. Dysfunction in bulk or non‐HCV‐specific CD8+ T‐cells in HCV infection has also been… read more here.
Keywords: protein; cd8; cd8 cells; hcv core ... See more keywords
Diagnostic Performance of the HCV Core Antigen Test To Identify Hepatitis C in HIV-Infected Patients: a Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01331-22
Abstract: The standard algorithm for diagnosing hepatitis C virus (HCV) infection has two steps, an HCV antibody test for screening and a nucleic acid amplification test (NAAT) for confirmation. However, the HCV core antigen (HCVcAg) detection… read more here.
Keywords: prevalence; test; hcv; analysis ... See more keywords
Variability of the HCV core region and host genetic and epigenetic factors can predict the response to pegylated interferon/ribavirin therapy in genotype 1B hepatitis C patients from Serbia
Sign Up to like & getrecommendations! Published in 2023 at "Archives of Biological Sciences"
DOI: 10.2298/abs230316020k
Abstract: Variations in the hepatitis C virus (HCV) core sequence have been related to disease progression and response to antiviral therapy. Previously we showed that the methylation status of RASSF1A and p16 genes, and IL28B genotypes… read more here.
Keywords: response pegylated; genotype; therapy; hcv core ... See more keywords
Hepatitis C Core Protein Induces a Genotype-Specific Susceptibility of Hepatocytes to TNF-Induced Death In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112521
Abstract: Hepatitis C virus (HCV) core protein is a multifunctional protein that is involved in the proliferation, inflammation, and apoptosis mechanism of hepatocytes. HCV core protein genetic variability has been implicated in various outcomes of HCV… read more here.
Keywords: core; tnf induced; core protein; hcv core ... See more keywords
Clinical Utility of HCV Core Antigen Detection and Quantification in the Diagnosis and Management of Patients with Chronic Hepatitis C Receiving an All-Oral, Interferon-Free Regimen
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Therapy"
DOI: 10.3851/imp3042
Abstract: Background The introduction of highly potent direct-acting combination therapies for HCV have negated the role of response-guided therapy and reduced the role of treatment monitoring. However, there remains a need to identify patients who are… read more here.
Keywords: core antigen; hcv core; hcv; hcv rna ... See more keywords
[Evaluation of the Correlation of HCV Core Antigen Levels with HCV RNA Levels in the Diagnosis and Treatment Follow-up of Hepatitis C Virus Infections].
Sign Up to like & getrecommendations! Published in 2023 at "Mikrobiyoloji bulteni"
DOI: 10.5578/mb.20239919
Abstract: Hepatitis C virus (HCV) infections are an important public health issue across the world because of the high risk of chronicity potential, impossibility of protection by vaccination and serious complications such as hepatocellular carcinoma. The… read more here.
Keywords: core antigen; hcv; hcv core; test ... See more keywords
Clinical utility of HCV core antigen detection and quantification using serum samples and dried blood spots in people who inject drugs in Dar-es-Salaam, Tanzania
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the International AIDS Society"
DOI: 10.7448/ias.20.1.21856
Abstract: Introduction: A lack of access to hepatitis C virus (HCV) diagnostics is a significant barrier to achieving the World Health Organization 2030 global elimination goal. HCV core antigen (HCVcAg) quantification and dried blood spot (DBS)… read more here.
Keywords: core antigen; inject drugs; hcv; dried blood ... See more keywords