Ledipasvir plus sofosbuvir as salvage therapy for HCV genotype 1 failures to prior NS5A inhibitors regimens
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24767
Abstract: There is little information on retreatment efficacy and predictors of the combination of ledipasvir and sofosbuvir (ledipasvir/sofosbuvir) for patients who fail to respond to NS5A inhibitors. NS5A resistance variants are known to persist for long… read more here.
Keywords: response; prior ns5a; treatment; hcv genotype ... See more keywords
Successful treatment of Japanese hemophilia patient co-infected with HIV and HCV genotype 4a by glecaprevir/pibrentasvir therapy
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-021-01524-1
Abstract: Although direct-acting antiviral (DAA)-based anti-hepatitis C virus (HCV) therapies are very effective for patients with genotypes 1 and 2, evidence of the efficacy of DAA-based therapy for the special population of patients with genotypes 3–6… read more here.
Keywords: treatment; hcv; hcv genotype; hiv hcv ... See more keywords
Comparison of cobas HCV GT against Versant HCV Genotype 2.0 (LiPA) with confirmation by Sanger sequencing.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of virological methods"
DOI: 10.1016/j.jviromet.2018.02.004
Abstract: BACKGROUND Correct identification of infecting hepatitis C virus (HCV) genotype is helpful for targeted antiviral therapy. OBJECTIVES Here, we compared the HCV genotyping performance of the cobas HCV GT assay against the Versant HCV Genotype… read more here.
Keywords: lipa; cobas hcv; hcv; genotype ... See more keywords
Regulatory Analysis of Effects of Hepatitis C Virus NS5A Polymorphisms on Efficacy of Elbasvir and Grazoprevir.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2016.10.017
Abstract: BACKGROUND & AIMS Elbasvir (an NS5A inhibitor) and grazoprevir (an NS3/4A protease inhibitor) are direct-acting antiviral agents recently approved in the United States for treatment of chronic hepatitis C virus (HCV) genotype 1 and 4… read more here.
Keywords: grazoprevir; elbasvir grazoprevir; treatment; hcv genotype ... See more keywords
Safety and Efficacy of Elbasvir/Grazoprevir in Patients With Hepatitis C Virus Infection and Compensated Cirrhosis: An Integrated Analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.01.050
Abstract: BACKGROUND & AIMS Persons with hepatitis C virus (HCV) infection are at risk of progressive liver disease, cirrhosis, and decompensation. We analyzed the effects of the direct-acting antiviral agents elbasvir and grazoprevir in patients with… read more here.
Keywords: elbasvir grazoprevir; treatment; infection; hcv genotype ... See more keywords
Virological characterization of treatment failures and retreatment outcomes in patients infected with "unusual" HCV genotype 1 subtypes.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000379
Abstract: BACKGROUND AIMS Suboptimal rates of sustained virological response (SVR) have been reported in patients infected with an "unusual", non-1a/1b hepatitis C virus (HCV) genotype 1 subtype. The objectives of this study were to assess the… read more here.
Keywords: infected unusual; hcv genotype; genotype; hcv ... See more keywords
Real life Egyptian experience of efficacy and safety of Simeprevir/Sofosbuvir therapy in 6211 chronic HCV genotype IV infected patients
Sign Up to like & getrecommendations! Published in 2017 at "Liver International"
DOI: 10.1111/liv.13266
Abstract: Major changes have emerged during the last few years in the therapy of chronic HCV. Several direct acting antiviral agents have been developed showing potent activity with higher rates of sustained virological response, even in… read more here.
Keywords: efficacy safety; chronic hcv; hcv genotype; real life ... See more keywords
Identification of recombinant strains in HCV genotype 1 and 3: Is it needed?
Sign Up to like & getrecommendations! Published in 2018 at "Liver International"
DOI: 10.1111/liv.13729
Abstract: Our reported data on surprisingly high prevalence of hepatitis C virus (HCV) recombinant genotype (GT) RF1_2k/1b in Georgia, which appears to be the highest so far reported worldwide, raised a question of probable existence and… read more here.
Keywords: recombinant strains; genotype; hcv genotype; identification recombinant ... See more keywords
Sofosbuvir based treatment of chronic hepatitis C genotype 3 infections—A Scandinavian real-life study
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179764
Abstract: Background and aims Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed the treatment outcome of sofosbuvir (SOF) based regimes for… read more here.
Keywords: treatment; hcv genotype; genotype; chronic hepatitis ... See more keywords
Novel HCV Genotype 4d Infectious Systems and Assessment of Direct-Acting Antivirals and Antibody Neutralization
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14112527
Abstract: Hepatitis C virus (HCV) genotype 4 is highly prevalent in the Middle East and parts of Africa. Subtype 4d has recently spread among high-risk groups in Europe. However, 4d infectious culture systems are not available,… read more here.
Keywords: antibody neutralization; hcv genotype; novel hcv; genotype ... See more keywords
HCV Genotype-3h, a Difficult-to-Diagnose Sub-Genotype in the DAA Era
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Therapy"
DOI: 10.3851/imp3228
Abstract: Background No data are available on the clinical presentation and virological pattern in the case of failure of interferon (IFN)-free regimens in patients with genotype-3h. In this paper authors identified the virological and clinical characteristics… read more here.
Keywords: daa; genotype; hcv genotype; patients genotype ... See more keywords