HCV-2a NS5A downregulates viral translation predominantly through domain I.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.177
Abstract: Hepatitis C virus (HCV) non-structural protein NS5A is a multifunctional protein with critical roles in viral replication and assembly. We previously showed that HCV-1b NS5A downregulates viral translation only in the presence of the poly(U/UC)… read more here.
Keywords: ns5a downregulates; downregulates viral; translation; hcv ns5a ... See more keywords
Design, synthesis and identification of silicon-containing HCV NS5A inhibitors with pan-genotype activity.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.025
Abstract: Modification of a HCV NS5A inhibitor, ombitasvir, led to the identification of 10d with improved pan-genotype NS5A inhibition and better pharmacokinetic properties. The key structural changes to ombitasvir include bioisosteric replacement of carbon with silicon… read more here.
Keywords: pan genotype; hcv; silicon containing; hcv ns5a ... See more keywords
Prodrug Strategies to Improve the Solubility of HCV NS5A Inhibitor Pibrentasvir (ABT-530).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00956
Abstract: A research program to discover solubilizing prodrugs of HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen via an oxymethyl linkage… read more here.
Keywords: inhibitor pibrentasvir; prodrug; ns5a inhibitor; hcv ns5a ... See more keywords
The Discovery of Conformationally Constrained Bicyclic Peptidomimetics as Potent Hepatitis C NS5A Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.1c00391
Abstract: HCV NS5A inhibitors are the backbone of directly acting antiviral treatments against the hepatitis C virus (HCV). While these therapies are generally highly curative, they are less effective in some specific HCV patient populations. In… read more here.
Keywords: conformationally constrained; discovery conformationally; hcv; chemistry ... See more keywords