Pharmacokinetics, Food Effect, Ketoconazole Interaction, and Safety of JTK‐853, a Novel Nonnucleoside HCV Polymerase Inhibitor, After Ascending Single and Multiple Doses in Healthy Subjects
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DOI: 10.1002/cpdd.656
Abstract: Pharmacokinetics, safety, and tolerability of JTK‐853, a novel HCV polymerase inhibitor, were evaluated in single and multiple ascending dose (SAD, MAD) studies, with food‐ and ketoconazole‐related effects on exposure to JTK‐853 and its active (CYP3A4… read more here.
Keywords: hcv polymerase; jtk 853; 853 novel; single multiple ... See more keywords
Molecular simulations to delineate functional conformational transitions in the HCV polymerase
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DOI: 10.1002/jcc.24662
Abstract: Hepatitis C virus (HCV) is a global health concern for which there is no vaccine available. The HCV polymerase is responsible for the critical function of replicating the RNA genome of the virus. Transitions between… read more here.
Keywords: delineate functional; hcv polymerase; simulations delineate; molecular simulations ... See more keywords