Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2017.04.012
Abstract: BACKGROUND The influence of immunosuppressants on hepatitis C virus (HCV) re-infection after liver transplantation, particularly mammalian target of rapamycin inhibitors, remains unclear. The aim of our study was to analyze the influence of everolimus (EVR)… read more here.
Keywords: replication activity; mammalian target; hcv replication; target rapamycin ... See more keywords
Interaction of miR-125b-5p with Human antigen R mRNA: Mechanism of controlling HCV replication.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2018.09.006
Abstract: Cellular miRNAs influence Hepatitis C virus (HCV) infection in multiple ways. In this study, we demonstrate that miR-125b-5p is upregulated in HCV infected patient serum samples as well as in HCV infected liver carcinoma cells… read more here.
Keywords: hcv replication; mir 125b; hur; human antigen ... See more keywords
The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31421-6
Abstract: Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues. OPN induces stemness by interacting with CD44, but the functional relevance of OPN-mediated interferon (IFN) signaling and hepatitis C virus… read more here.
Keywords: epcam cd44; ifn signaling; hcv replication; opn ... See more keywords
Haem oxygenase‐1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Sign Up to like & getrecommendations! Published in 2017 at "Liver International"
DOI: 10.1111/liv.13347
Abstract: Enhancement of host anti‐oxidant enzymes, such as haemoxygenase‐1, may attenuate virus‐mediated hepatocyte injury, while the induction of HO‐1 by cobalt‐protoporphyrin‐IX (CoPP) administration, as the application of its haem degradation product biliverdin (BV), was shown to… read more here.
Keywords: affect hcv; oxygenase polymorphisms; polymorphisms affect; hcv replication ... See more keywords
HCV NS5A dimer interface residues regulate HCV replication by controlling its self-interaction, hyperphosphorylation, subcellular localization and interaction with cyclophilin A
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007177
Abstract: The HCV NS5A protein plays multiple roles during viral replication, including viral genome replication and virus particle assembly. The crystal structures of the NS5A N-terminal domain indicated the potential existence of the NS5A dimers formed… read more here.
Keywords: ns5a self; ns5a dimer; hcv replication; interaction ... See more keywords
Differential Effects of Autophagy-Related 10 Protein on HCV Replication and Autophagy Flux Are Mediated by Its Cysteine44 and Cysteine135
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02176
Abstract: Autophagy-related 10 (ATG10) is essential for autophagy since it promotes ATG5-ATG12 complex formation. Our previous study found that there are two isoforms of the ATG10 protein, ATG10 (a longer one) and ATG10S, which have identical… read more here.
Keywords: replication autophagy; hcv replication; cys44 cys135; replication ... See more keywords
GRIM-19 Restricts HCV Replication by Attenuating Intracellular Lipid Accumulation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00576
Abstract: Gene-associated with retinoid-interferon-induced mortality 19 (GRIM-19) targets multiple signaling pathways involved in cell death and growth. However, the role of GRIM-19 in the pathogenesis of hepatitis virus infections remains unexplored. Here, we investigated the restrictive… read more here.
Keywords: intracellular lipid; lipid accumulation; hcv replication; attenuating intracellular ... See more keywords
The Role of the Liver-Specific microRNA, miRNA-122 in the HCV Replication Cycle
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DOI: 10.3390/ijms21165677
Abstract: Hepatitis C virus (HCV) replication requires annealing of a liver specific microRNA, miR-122 to 2 sites on 5′ untranslated region (UTR). While, microRNAs downregulate gene expression by binding to the 3′ untranslated region of the… read more here.
Keywords: specific microrna; liver specific; hcv replication; mir 122 ... See more keywords
Plant-Derived Purification, Chemical Synthesis, and In Vitro/In Vivo Evaluation of a Resveratrol Dimer, Viniferin, as an HCV Replication Inhibitor
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DOI: 10.3390/v11100890
Abstract: Oligostilbenoid compounds, a group of resveratrol multimers, display several anti-microbial activities through the neutralization of cytotoxic oxidants, and by inhibiting essential host and viral enzymes. In our previous study, we identified a series of oligostilbenoid… read more here.
Keywords: hcv replication; anti hcv; hcv; resveratrol dimer ... See more keywords
Silencing HCV Replication in Its Reservoir
Sign Up to like & getrecommendations! Published in 2018 at "Open Access Macedonian Journal of Medical Sciences"
DOI: 10.3889/oamjms.2018.372
Abstract: BACKGROUND: HCV infection and its complications are among the leading public health challenges; the emergence of drug-resistant variants are expected to be a major problem. A novel combinatorial small interfering RNA (siRNA) could be a… read more here.
Keywords: reservoir; hcv; hcv replication; sirna ... See more keywords