Dysregulated homocysteine metabolism and cardiovascular disease and clinical treatments
Sign Up to like & getrecommendations! Published in 2025 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-025-05284-1
Abstract: Elevated homocysteine (Hcy) levels, known as hyperhomocysteinemia (HHcy), are recognized as a separate risk factor for cardiovascular disease. Mutations in methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta synthase (CBS)—enzymes pivotal at the juncture of the trans-sulfuration… read more here.
Keywords: hcy; cardiovascular disease; metabolism; hcy levels ... See more keywords
Association between plasma homocysteine levels and cognitive deficits in Han Chinese patients with schizophrenia across age groups
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DOI: 10.1038/s41598-021-99239-3
Abstract: It was still unclear how homocysteine (Hcy) levels and cognitive deficits change in patients with schizophrenia of various ages. The present article attempts to assess the relationship between Hcy levels and cognitive deficits in patients… read more here.
Keywords: cognitive deficits; patients schizophrenia; age; levels cognitive ... See more keywords
Relationship between elevated homocysteine levels and the degree of white matter lesions in stroke patients
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DOI: 10.1097/md.0000000000041984
Abstract: This study explores the relationship between elevated homocysteine (Hcy) levels and white matter lesion (WML) severity in stroke patients, aiming to clarify Hcy role in stroke pathology and support clinical treatment and prevention strategies for… read more here.
Keywords: relationship elevated; cimt; stroke patients; elevated homocysteine ... See more keywords
Establishment of a prediction model for venous thromboembolism in patients with acute exacerbation of chronic obstructive pulmonary disease based on serum homocysteine levels and Wells scores: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-024-04270-7
Abstract: We evaluated the diagnostic value of homocysteine (Hcy) levels combined with the Wells score and established a prediction model for venous thromboembolism (VTE) occurrence in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD)… read more here.
Keywords: hcy; prediction; levels wells; model ... See more keywords
Application of Periventricular White Matter Hyperintensities Combined with Homocysteine into Predicting Mild Cognitive Impairment in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s399307
Abstract: Purpose To verify the associations between white matter hyperintensities (WMHs), plasma homocysteine (Hcy) levels, and mild cognitive impairment (MCI) in Parkinson’s disease (PD) patients and evaluate the predictive value of combination of WMHs and plasma… read more here.
Keywords: hcy levels; white matter; mild cognitive; hcy ... See more keywords
Homocysteine and Clinical Outcomes in Intracerebral Hemorrhage Patients: Results from the China Stroke Center Alliance
Sign Up to like & getrecommendations! Published in 2022 at "Neuropsychiatric Disease and Treatment"
DOI: 10.2147/ndt.s391618
Abstract: Objective Elevated homocysteine (Hcy) levels play a detrimental role in ischemic stroke. Acute spontaneous intracerebral hemorrhage (ICH) accounts for nearly 25% of all stroke cases. However, the influence of Hcy levels and ICH severity on… read more here.
Keywords: clinical outcomes; hcy levels; outcome; hcy ... See more keywords
Increased Carotid Intima-Media Thickness (IMT) in Hyperuricemic Individuals May Be Explained by Hyperhomocysteinemia Associated with Renal Dysfunction: a Cross-Sectional Study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Korean Medical Science"
DOI: 10.3346/jkms.2019.34.e237
Abstract: Background Both hyperuricemia and hyperhomocysteinemia are known as main risk factors of cardiovascular diseases. There has been, however, no report on the relationship between carotid intima-media thickness (IMT) and homocysteine (Hcy) in hyperuricemic patients. This… read more here.
Keywords: serum hcy; carotid; study; hyperhomocysteinemia ... See more keywords
Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1051047
Abstract: Background: Currently, it is unclear whether there is a causal association between genetically predicted plasma homocysteine (Hcy) levels and the risk of sarcopenia. We performed a Mendelian randomization (MR) study to assess the association between… read more here.
Keywords: levels components; hcy levels; effect; mendelian randomization ... See more keywords
Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.931560
Abstract: Background Cognitive impairment in late−life depression (LLD) is considered to be caused by neurodegenerative changes. Elevated homocysteine (Hcy) levels may be linked to cognitive abnormalities associated with LLD. The important role of white matter (WM)… read more here.
Keywords: patients lld; hcy levels; late life; elevated homocysteine ... See more keywords
Association of plasma homocysteine with cognitive impairment in patients with Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2024.1434943
Abstract: Background Elevated plasma homocysteine (Hcy) has been reported as a risk factor for cognitive impairment in the general population. However, there are conflicting results regarding the relationship between Hcy and cognitive impairment across various cognitive… read more here.
Keywords: cognitive impairment; plasma homocysteine; hcy; plasma hcy ... See more keywords
Elevated Plasma Homocysteine Levels in Anti-N-methyl-D-aspartate Receptor Encephalitis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00464
Abstract: Objective: Homocysteine (Hcy) levels have been investigated in many diseases, such as neurodegenerative and autoimmune diseases. However, changes in Hcy levels in anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis have not been investigated thus far. Methods: Case data… read more here.
Keywords: homocysteine; anti nmdar; encephalitis; nmdar encephalitis ... See more keywords