Hydroxamic Acid-Modified Peptide Library Provides Insights into the Molecular Basis for the Substrate Selectivity of HDAC Corepressor Complexes
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DOI: 10.1021/acschembio.2c00510
Abstract: Targeting the lysine deacetylase activity of class I histone deacetylases (HDACs) is potentially beneficial for the treatment of several diseases including human immunodeficiency virus (HIV) infection, Alzheimer’s disease, and various cancers. It is therefore important… read more here.
Keywords: hdac corepressor; corepressor complexes; acid; substrate ... See more keywords