Design, synthesis, and biological evaluation of novel amide and hydrazide based thioether analogs targeting Histone deacteylase (HDAC) enzymes.
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DOI: 10.1016/j.ejmech.2018.02.011
Abstract: Development of HDAC inhibitors have become an ultimate need targeting different types of cancer. In silico virtual screening was applied to screen novel scaffolds via scaffold hopping strategy to develop different acrylamide and aryl/heteroaryl hydrazide… read more here.
Keywords: hydrazide based; cell lines; based analogs; hdac ... See more keywords