Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer.
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DOI: 10.1016/j.ejmech.2020.112322
Abstract: In the current study, we have designed and synthesized a series of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent kinase2 (CDK2) dual inhibitors by integrating purine-based pharmacophore into the recognition cap group of CS055. The representative… read more here.
Keywords: novel histone; cyclin dependent; cdk2; hdac1 cyclin ... See more keywords