Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells
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DOI: 10.1021/acs.jmedchem.1c02179
Abstract: Class I histone deacetylase (HDAC) enzymes 1, 2, and 3 organize chromatin as the catalytic subunits within seven distinct multiprotein corepressor complexes and are established drug targets. We report optimization studies of benzamide-based Von Hippel–Lindau… read more here.
Keywords: class histone; hdac1 degradation; histone deacetylase; apoptosis ... See more keywords