First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200180
Abstract: Histone deacetylases (HDACs) are important epigenetic regulators involved in many diseases, especially cancer. Five HDAC inhibitors have been approved for anticancer therapy and many are in clinical trials. Among the 11 zinc‐dependent HDACs, HDAC10 has… read more here.
Keywords: assay hdac10; deacetylation; cellular target; target engagement ... See more keywords
HDAC10 as a potential therapeutic target in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.01.009
Abstract: OBJECTIVE We analyzed histone deacetylase 10 (HDAC10) for function in the context of the DNA damage response in BRCA1-null ovarian cancer cells as well as evaluated the potential of general HDAC inhibitors in primary ovarian… read more here.
Keywords: platinum; dna; hdac10; ovarian cancer ... See more keywords
Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00362
Abstract: The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy… read more here.
Keywords: selective inhibition; polyamine deacetylase; hdac10; polyamine ... See more keywords
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abo4356
Abstract: Histone deacetylases (HDACs) play important roles in immunity and inflammation. Through functional screening, we identified HDAC10 as an inhibitor of the type I interferon (IFN) response mediated by interferon regulatory factor 3 (IRF3). HDAC10 abundance… read more here.
Keywords: response; innate immune; hdac10; type ... See more keywords
HDAC10 Inhibits Cervical Cancer Progression through Downregulating the HDAC10-microRNA-223-EPB41L3 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/8092751
Abstract: Background Although the tumorigenesis of cervical cancer (CC) has been widely investigated and recognized, the study of the systematic impact of histone deacetylase 10 (HDAC10), microRNA, and downstream molecular mechanisms in CC is still limited.… read more here.
Keywords: cervical cancer; mir 223; 223 epb41l3; cancer ... See more keywords
HDAC10 promotes angiogenesis in endothelial cells through the PTPN22/ERK axis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18130
Abstract: Angiogenesis is crucially involved in many physiological and pathological processes including tumor growth, but the molecular mechanisms regulating angiogenesis are incompletely understood. In this study, we investigated the functions and mechanism of histone deacetylase 10… read more here.
Keywords: hdac10; endothelial cells; hdac10 promotes; angiogenesis endothelial ... See more keywords