Effects of dexmedetomidine on cognitive dysfunction and neuroinflammation via the HDAC2/HIF‐1α/PFKFB3 axis in a murine model of postoperative cognitive dysfunction
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23044
Abstract: Inhibition of histone deacetylase (HDAC) may be a useful approach in the treatment of disorders characterized by cognitive dysfunction. Dexmedetomidine (DEX), an α2‐adrenoceptor (α2‐AR) agonist, has demonstrated neuroprotective effects. Here, we attempted to investigate the… read more here.
Keywords: cognitive dysfunction; hif pfkfb3; dysfunction; hdac2 ... See more keywords
Origin of the kinetic HDAC2‐selectivity of an HDAC inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.27111
Abstract: A newly synthesized small molecule, KTT‐1, exhibits kinetically selective inhibition of histone deacetylase 2, HDAC2, over its homologous enzyme, HDAC1. KTT‐1 is hard to be released from the HDAC2/KTT‐1 complex, compared to the HDAC1/KTT‐1 complex… read more here.
Keywords: ktt; selectivity; hdac1; hdac2 ... See more keywords
HDAC2‐mediated proliferation of trophoblast cells requires the miR‐183/FOXA1/IL‐8 signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30026
Abstract: Pre‐eclampsia (PE) is a major cause of maternal and perinatal death. Previous research has indicated the role of histone deacetylase 2 (HDAC2) in the pathogenesis of PE but the relevant molecular mechanisms are unknown. However,… read more here.
Keywords: proliferation migration; hdac2; mir 183; proliferation ... See more keywords
HDAC2 exacerbates rheumatoid arthritis progression via the IL-17-CCL7 signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23802
Abstract: Histone deacetylases (HDACs) have been reported to regulate the immune response in rheumatoid arthritis (RA). The current study aimed to explore key HDACs and their molecular mechanism in RA. First, the expression of HDAC1, HDAC2,… read more here.
Keywords: signaling pathway; hdac2; progression; rheumatoid arthritis ... See more keywords
Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes
Sign Up to like & getrecommendations! Published in 2021 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-021-00855-x
Abstract: Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key role for epigenetic mechanisms in the regulation of ion channel expression. Histone deacetylases (HDACs)… read more here.
Keywords: atrial fibrillation; hdac2; channel expression; regulation ... See more keywords
Astrocytic c-Jun N-terminal kinase-histone deacetylase-2 cascade contributes to glutamate transporter-1 decrease and mechanical allodynia following peripheral nerve injury in rats
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.07.024
Abstract: Decrease of glutamate transporter-1 (GLT-1) in the spinal dorsal horn after nerve injury induces enhanced excitatory transmission and causes persistent pain. Histone deacetylases (HDACs)-catalyzed deacetylation might contribute to the decrease of GLT-1, while the detailed… read more here.
Keywords: hdac2; glutamate transporter; decrease; nerve injury ... See more keywords
MiR-646 prevents proliferation and progression of human breast cancer cell lines by suppressing HDAC2 expression.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2020.101649
Abstract: BACKGROUND Breast cancer is a type of cancer with a high incidence and mortality rate worldwide. Change in epigenetic mechanisms enhances cancer cell progression. Histon deacetylase 2 (HDAC2) was found to act as a potential… read more here.
Keywords: hdac2; breast cancer; cancer; cell ... See more keywords
Nonylphenol regulates TL1A through the AhR/HDAC2/HNF4α pathway in endothelial cells to promote the angiogenesis of colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115854
Abstract: BACKGROUND Colorectal cancer (CRC) is one of the most malignant cancers worldwide. Nonylphenol (NP) is an endocrine-disruptor chemical and plays an important role in the development of cancers. However, the effects of NP on CRC… read more here.
Keywords: angiogenesis; hdac2 hnf4; hdac2; ahr hdac2 ... See more keywords
Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00272
Abstract: Fragment-based ligand discovery was successfully applied to histone deacetylase HDAC2. In addition to the anticipated hydroxamic acid- and benzamide-based fragment screening hits, a low affinity (∼1 mM) α-amino-amide zinc binding fragment was identified, as well… read more here.
Keywords: fragment based; brain penetrant; hdac2 inhibitor; hdac2 ... See more keywords
The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08225-3
Abstract: The biological role of miR-500a-5p has not yet been reported in the context of colorectal cancer (CRC). Here, we show that miR-500a-5p expression is decreased in CRC tissues compared with adjacent normal tissues. Low miR-500a-5p… read more here.
Keywords: hdac2; mir 500a; colorectal cancer; p300 yy1 ... See more keywords
HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41842-6
Abstract: Both HDAC1 and HDAC2 are class I deacetylases acting as erasers of lysine-acetyl marks on histones and non-histone proteins. Several histone deacetylase inhibitors, either endogenous to the cell, such as the ketogenic β-hydroxybutyrate metabolite, or… read more here.
Keywords: hdac2; iec; hdac1 hdac2; hdac2 independently ... See more keywords