Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103887
Abstract: Cancer cells are addicted to glutamine. However, cancer cells often suffer from glutamine starvation, which largely results from the fast growth of cancer cells and the insufficient vascularization in the interior of cancer tissues. Herein,… read more here.
Keywords: cancer; liver cancer; glutamine starvation; hdac3 ... See more keywords
Downregulation of HDAC3 by ginsenoside Rg3 inhibits epithelial–mesenchymal transition of cutaneous squamous cell carcinoma through c‐Jun acetylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28788
Abstract: The metastatic rate of human cutaneous squamous cell carcinoma (CSCC) has increased in recent years. Despite the current advances in therapies, effective treatments remain lacking. Ginsenoside 20(R)‐Rg3 is an effective antitumor monomer extracted from ginseng,… read more here.
Keywords: jun acetylation; rg3; hdac3; cell ... See more keywords
Circular RNA ACACA negatively regulated p53‐modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR‐193a/b‐3p/HDAC3 axis
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23522
Abstract: This study aimed to explore the biological functions and underlying mechanism of circRNA acetyl‐CoA carboxylase alpha (circACACA) in colorectal cancer (CRC). The RNA and protein levels were detected by qRT‐PCR and western blot assays. The… read more here.
Keywords: pathway; circacaca; crc; p53 ... See more keywords
Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02141-8
Abstract: Development and progression of many kidney diseases are substantially influenced by aberrant protein acetylation modifications of gene expression crucial for kidney functions. Histone deacetylase (HDAC) expression alterations are detected from renal samples of patients and… read more here.
Keywords: kidney diseases; disease; histone deacetylase; hdac3 ... See more keywords
HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1/STAT3 Signaling Pathway Through miR-19a Upregulation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02325-w
Abstract: Histone deacetylase (HDAC) inhibitors can protect the brain from ischemic injury. This study aimed to identify the regulation of HDAC3 in cerebral ischemic injury. Middle cerebral artery occlusion (MCAO) was performed to establish a mouse… read more here.
Keywords: ischemic injury; jak1 stat3; mir 19a; hdac3 ... See more keywords
HDAC3 protects against atherosclerosis through inhibition of inflammation via the microRNA-19b/PPARγ/NF-κB axis.
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.02.013
Abstract: BACKGROUND AND AIMS Atherosclerosis (AS) is one of the leading causes of cardiovascular diseases. Studies have revealed critical roles of microRNAs (miRNAs) in the progression of AS. This study was conducted to elucidate the role… read more here.
Keywords: ppar; mir 19b; inflammation; hdac3 ... See more keywords
Habits Are Negatively Regulated by Histone Deacetylase 3 in the Dorsal Striatum
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2018.01.025
Abstract: BACKGROUND Optimal behavior and decision making result from a balance of control between two strategies, one cognitive/goal-directed and one habitual. These systems are known to rely on the anatomically distinct dorsomedial and dorsolateral striatum, respectively.… read more here.
Keywords: dorsal striatum; striatum; dorsolateral striatum; hdac3 ... See more keywords
HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.11.045
Abstract: Summary The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated… read more here.
Keywords: state; transition; cell state; myelinating schwann ... See more keywords
HDAC3 is a potential validated target for cancer: An overview on the benzamide-based selective HDAC3 inhibitors through comparative SAR/QSAR/QAAR approaches.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.081
Abstract: Deacetylation of histones by histone deacetylase 3 (HDAC3) is involved in apoptosis, cellular progression and DNA damage. Due to the overexpression of HDAC3 in a variety of cancers, it is implicated to be a crucial… read more here.
Keywords: hdac3 inhibitors; selective hdac3; target cancer; qsar qaar ... See more keywords
HDAC3 inhibitor RGFP966 controls bacterial growth and modulates macrophage signaling during Mycobacterium tuberculosis infection.
Sign Up to like & getrecommendations! Published in 2021 at "Tuberculosis"
DOI: 10.1016/j.tube.2021.102062
Abstract: RATIONALE Host-directed therapeutics for Mycobacterium tuberculosis (Mtb) offer potential strategies for combatting antibiotic resistance and for killing non-replicating bacilli. Phenylbutyrate, a partially selective histone-deacetylase (HDAC) inhibitor, was previously shown to control Mtb growth and alter… read more here.
Keywords: inhibitor; mtb; hdac3; growth ... See more keywords
Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion
Sign Up to like & getrecommendations! Published in 2017 at "Nature Medicine"
DOI: 10.1038/nm.4245
Abstract: Type 2 diabetes and insulin resistance are associated with reduced glucose utilization in the muscle and poor exercise performance. Here we find that depletion of the epigenome modifier histone deacetylase 3 (HDAC3) specifically in skeletal… read more here.
Keywords: insulin; muscle; mice; hdac3 ... See more keywords