HDAC3 inhibition improves urinary‐concentrating defect in hypokalaemia by promoting AQP2 transcription
Sign Up to like & getrecommendations! Published in 2022 at "Acta Physiologica"
DOI: 10.1111/apha.13802
Abstract: This study investigated whether enhanced histone acetylation, achieved by inhibiting histone deacetylases (HDACs), could prevent decreased aquaporin‐2 (AQP2) expression during hypokalaemia. read more here.
Keywords: inhibition improves; hdac3 inhibition; hypokalaemia; concentrating defect ... See more keywords
HDAC3 Inhibition Alleviates High-Glucose-Induced Retinal Ganglion Cell Death through Inhibiting Inflammasome Activation
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4164824
Abstract: Purpose The exact effects of histone deacetylase 3 (HDAC3) inhibition in DR related retinal ganglion cells (RGCs) death remained unclear. This study is aimed at detecting the influence of HDAC3 on the high-glucose-induced retinal ganglion… read more here.
Keywords: cell; hdac3 inhibition; high glucose; retinal ganglion ... See more keywords
HDAC3 Inhibition Promotes Antitumor Immunity by Enhancing CXCL10-Mediated Chemotaxis and Recruiting of Immune Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0317
Abstract: Histone deacetylase 3 (HDAC3) is shown to regulate expression of genes encoding chemokines CXCL9/10/11, as well as impact antitumor immune–cell recruitment in the tumor microenvironment. The data highlight how targeting HDAC3 could boost antitumor immune… read more here.
Keywords: promotes antitumor; inhibition promotes; hdac3 inhibition; immunity enhancing ... See more keywords