LncRNA MALAT1 promotes decidualization of endometrial stromal cells via sponging miR‐498‐3p and targeting histone deacetylase 4
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11814
Abstract: Decidualization of human endometrial stromal cells (hESCs) is important for the maintenance of a successful pregnancy. Histone deacetylase 4 (HDAC4) was reported to be involved in the dysfunction of decidua‐derived mesenchymal stem cells. However, the… read more here.
Keywords: mir 498; endometrial stromal; hescs; hdac4 ... See more keywords
PTHrP promotes development of mouse preimplantation embryos through the AKT/cyclin D1 pathway and nuclear translocation of HDAC4
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30362
Abstract: Parathyroid hormone‐related protein (PTHrP), the main cause of humoral hypercalcemia in malignancies, promotes cell proliferation and delays terminal cell maturation during embryonic development. Our previous study reported that PTHrP plays important roles in blastocyst formation,… read more here.
Keywords: pthrp; hdac4; embryonic development; preimplantation ... See more keywords
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12891
Abstract: BACKGROUND Histone deacetylase 4 (HDAC4) is a stress-responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never… read more here.
Keywords: hdac4; membrane repair; muscular dystrophy; muscle ... See more keywords
HDAC4 Knockdown Induces Preeclampsia Cell Autophagy and Apoptosis by miR-29b
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00286-4
Abstract: Preeclampsia (PE) is one of the main causes of maternal death and perinatal morbidity and mortality. Considering that histone deacetylase 4 (HDAC4) activity could relate to trophoblast cell motility and be antagonized by miR-29b, the… read more here.
Keywords: autophagy apoptosis; hdac4; trophoblast; mir 29b ... See more keywords
Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2022.01.013
Abstract: BACKGROUND Multiple myeloma (MM) is a malignant tumor of plasma cells in the bone marrow. Circular RNAs (circRNAs) exert important activity in the tumorigenesis and chemoresistance of MM. In the current work, we sought to… read more here.
Keywords: mir 331; apoptosis; proliferation; cell ... See more keywords
Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101669
Abstract: NADPH oxidases produce reactive oxygen species that differ in localization, type and concentration. Within the Nox family only Nox4 produces H2O2 which can directly oxidize cysteine residues. With this post-translational modification, activity, stability, localization and… read more here.
Keywords: overexpression; nox4 derived; hdac4; tube formation ... See more keywords
Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00601-1
Abstract: Histone deacetylases (HDACs) and microRNAs (miRs) have been reported to exert pivotal roles on the pathogenesis of myocardial ischemia-reperfusion injury (MIRI). Therefore, the present study was performed to define the underlying role of HDAC4 and… read more here.
Keywords: mekk1; jnk; hdac4; mir 206 ... See more keywords
HDAC4 Mediates Smoking-Induced Pancreatic Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Pancreas"
DOI: 10.1097/mpa.0000000000001998
Abstract: Objective Cigarette smoking is an established risk factor for pancreatic ductal adenocarcinoma (PDAC). In this project, we investigated the effect of smoking and the role of histone deacetylase 4 (HDAC4) in PDAC invasion and metastasis.… read more here.
Keywords: pdac; metastasis; invasion; smoking induced ... See more keywords
Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12861
Abstract: Early dysfunction in Alzheimer's disease (AD) is characterised by alterations of synapse structure and function leading to dysmorphic neurites, decreased spine density, impaired synaptic plasticity and cognitive deficits. The class II member HDAC4, which recently… read more here.
Keywords: function; alzheimer disease; hdac4 recovers; cytoplasmic hdac4 ... See more keywords
HDAC4 Inhibitors as Antivascular Senescence Therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3087916
Abstract: Aging is an inevitable consequence of life, and during this process, the epigenetic landscape changes and reactive oxygen species (ROS) accumulation increases. Inevitably, these changes are common in many age-related diseases, including neurodegeneration, hypertension, and… read more here.
Keywords: hdac4 inhibitors; senescence therapeutics; antivascular senescence; hdac4 ... See more keywords
KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1
Sign Up to like & getrecommendations! Published in 2022 at "Gerontology"
DOI: 10.1159/000524029
Abstract: Objectives: Atherosclerosis (AS) remains a major contributor to death worldwide. This study sought to explore the role of Krüppel-like factor 7 (KLF7) in AS lesions via regulating glucose metabolic reprogramming (GMR) in macrophages. Methods: AS… read more here.
Keywords: klf7; 148b ncor1; metabolic reprogramming; hdac4 ... See more keywords