Bidirectional regulation of HDAC5 by mAKAPβ signalosomes in cardiac myocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.03.001
Abstract: Class IIa histone deacetylases (HDACs) are transcriptional repressors whose nuclear export in the cardiac myocyte is associated with the induction of pathological gene expression and cardiac remodeling. Class IIa HDACs are regulated by multiple, functionally… read more here.
Keywords: cardiac myocytes; nuclear export; makap; hdac5 ... See more keywords
P0684HDAC5/KLF2 AXIS REGULATES NLRP3 MEDIATED RENAL INFLAMMATION AND FIBROSIS ASSOCIATED WITH NEPHROCALCINOSIS-RELATED CHRONIC KIDNEY DISEASE
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0684
Abstract: Role of epigenetic factors like histone deacetylases (HDACs) is largely unexplored in the pathogenesis of Nephrocalcinosis-related chronic kidney disease. The present study was performed to evaluate the functional role of HDAC5 in fibroblast activation in… read more here.
Keywords: pba; hdac5; expression; nephrocalcinosis related ... See more keywords
Inflammation leads through PGE/EP 3 signaling to HDAC5/MEF2‐dependent transcription in cardiac myocytes
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201708536
Abstract: The myocyte enhancer factor 2 (MEF2) regulates transcription in cardiac myocytes and adverse remodeling of adult hearts. Activators of G protein‐coupled receptors (GPCRs) have been reported to activate MEF2, but a comprehensive analysis of GPCR… read more here.
Keywords: cardiac myocytes; mef2; hdac5; cardiac ... See more keywords
Dexmedetomidine attenuates the toxicity of β‑amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular medicine reports"
DOI: 10.3892/mmr.2018.9694
Abstract: Cytotoxicity of β-Amyloid (Aβ) is a major contributor to the pathogenesis of Alzheimer's disease. Dexmedetomidine (Dex) has been revealed to have multiple neuroprotective actions as a clinical anesthetic agent. The aim of the present study… read more here.
Keywords: dex; dexmedetomidine; bdnf production; hdac5 ... See more keywords
HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.69444
Abstract: Rationale: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal 5-year survival less than 10%. Most patients with PDAC exhibit poor response to single-agent immunotherapy. Multimodal therapies targeting mechanisms of resistance to immunotherapy… read more here.
Keywords: cancer; hdac5; immunity; modulates expression ... See more keywords