Protein kinase B/AKT mediates insulin‐like growth factor 1‐induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28353
Abstract: Insulin‐like growth factor 1 (IGF‐1) mediates the generation of reactive oxygen species (ROS) and the activation of growth promoting signaling pathways. Histone deacetylases (HDACs) regulate gene transcription by deacetylating lysine residues in histone and nonhistone… read more here.
Keywords: hdac5 phosphorylation; nuclear export; igf; activation ... See more keywords
WNT10A induces apoptosis of senescent synovial resident stem cells through WNT/calcium pathway-mediated HDAC5 phosphorylation in OA joints.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116006
Abstract: Recently, the accumulation of senescent cells (SnCs) within joints was found to promote osteoarthritis (OA) progression. Our previous study found that Wnt proteins, especially Wnt10a, have marked effects on cellular senescence and joint health. However,… read more here.
Keywords: synovial resident; stem cells; hdac5 phosphorylation; wnt calcium ... See more keywords