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   Articles with "hdac6" as a keyword



Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202412921

Abstract: HDAC6 is integral to the regulation of primary cilia, which are specialized structures that serve as crucial signaling hubs for cellular communication and environmental response. These ciliary functions are essential for maintaining cellular homeostasis and… read more here.

Keywords: hdac6 ciliopathies; deacetylase hdac6; emerging insights; hdac6 ... See more keywords

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202501553

Abstract: Glioblastoma (GBM) is the most common and the deadliest brain cancer. Glutamine anabolism mediated by glutamine synthetase (GS) is beneficial for GBM cell growth, especially under glutamine deprivation. However, the molecular mechanism underlying GS homeostasis… read more here.

Keywords: glutamine metabolism; hdac6 usp9x; tumorigenesis; glioblastoma ... See more keywords

Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors

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recommendations! Published in 2020 at "Chemmedchem"

DOI: 10.1002/cmdc.202000149

Abstract: We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two… read more here.

Keywords: design synthesis; hdac6 inhibitors; dihydroxamic acids; synthesis dihydroxamic ... See more keywords

The Leupaxin/HDAC6/EGR2 axis facilitates breast cancer progression by enhancing macrophage M2 polarization

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recommendations! Published in 2025 at "Cell Biology and Toxicology"

DOI: 10.1007/s10565-025-10088-6

Abstract: Macrophage M2 polarization plays a pivotal role in breast cancer development. The present study aimed to investigate the interplay of the Leupaxin (LPXN)/HDAC6/EGR2 axis in breast cancer and its impact on macrophage M2 polarization. Our… read more here.

Keywords: cancer; breast cancer; macrophage polarization; hdac6 ... See more keywords

Developing potent PROTACs tools for selective degradation of HDAC6 protein

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recommendations! Published in 2019 at "Protein & Cell"

DOI: 10.1007/s13238-018-0602-z

Abstract: Histone deacetylases (HDACs) are a family of enzymes that remove acetyl groups on histone and non-histone proteins, thereby playing a vital role in the modulation of gene expression and protein activity. Eighteen HDACs have been… read more here.

Keywords: degradation; protacs; hdac6; cell ... See more keywords

HDAC6 deficiency induces apoptosis in mesenchymal stem cells through p53 K120 acetylation.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.10.087

Abstract: The acetylation of p53 is critical in modulating its pro-apoptotic roles. However, its regulatory mechanism and physiological significance are unclear. Here, we show HDAC6 negatively regulates pro-apoptotic acetylation of p53 at lysine residue 120 (K120) in… read more here.

Keywords: acetylation; k120 acetylation; hdac6; p53 ... See more keywords

Discovery of specific HDAC6 inhibitor with anti-metastatic effects in pancreatic cancer cells through virtual screening and biological evaluation.

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recommendations! Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.103679

Abstract: Histone deacetylase 6 (HDAC6) has been demonstrated to play a major role in cell motility and aggresome formation, and HDAC6 inhibition is therefore considered as a promising epigenetic strategy for cancer treatment. At present, only… read more here.

Keywords: virtual screening; hdac6 inhibitors; cefoperazone sodium; cancer ... See more keywords
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Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo.

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recommendations! Published in 2021 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2021.105081

Abstract: Selective inhibition of histone deacetylase 6 (HDAC6) has been emerged as a promising approach to cancer treatment. As a pivotal strategy for drug discovery,molecular hybridization was introduced in this study and a series of pyrrolo[2,1-c][1,4]… read more here.

Keywords: hdac6 inhibitors; vitro vivo; metastasis; selective hdac6 ... See more keywords

MAP3K4 Controls the Chromatin Modifier HDAC6 during Trophoblast Stem Cell Epithelial-to-Mesenchymal Transition.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.02.030

Abstract: The first epithelial-to-mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TSKI4 cells) induces an intermediate state of EMT, where cells retain stemness, lose… read more here.

Keywords: mesenchymal transition; map3k4; epithelial mesenchymal; hdac6 ... See more keywords

HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.

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recommendations! Published in 2017 at "Developmental cell"

DOI: 10.1016/j.devcel.2017.09.001

Abstract: Age-dependent ectopic fat accumulation (EFA) in animals contributes to the progression of tissue aging and diseases such as obesity, diabetes, and cancer. However, the primary causes of age-dependent EFA remain largely elusive. Here, we characterize… read more here.

Keywords: age dependent; age; proteostasis; plin2 ... See more keywords

TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia.

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recommendations! Published in 2020 at "Journal of pharmacological sciences"

DOI: 10.1016/j.jphs.2020.06.007

Abstract: Microglia maintain brain homeostasis as the main immune cells in the central nervous system. Activation of sigma-1 receptor (Sig1R) plays neuroprotective and anti-inflammatory roles in microglia. Recent studies showed that Sig1R expression level has been… read more here.

Keywords: sig1r; tak1 p38; expression; hdac6 ... See more keywords