Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.03.029
Abstract: Summary Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs degenerate resulting in muscle atrophy. The aim of this study was to… read more here.
Keywords: hdac6 inhibition; microfluidic devices; human motor; fus mutations ... See more keywords
HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy
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DOI: 10.1097/j.pain.0000000000000893
Abstract: Abstract Chemotherapy-induced peripheral neuropathy is one of the most common dose-limiting side effects of cancer treatment. Currently, there is no Food and Drug Administration–approved treatment available. Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase whose… read more here.
Keywords: hdac6 inhibition; peripheral neuropathy; inhibition; cisplatin ... See more keywords
Class 1 HDAC and HDAC6 inhibition inversely regulates CD38 induction in myeloma cells via interferon‐α and ATRA
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15673
Abstract: Additional supporting information may be found online in the Supporting Information section at the end of the article. Table SI. Ion AmpliSeq hematology panel (custom design, University Medical Center Utrecht, the Netherlands). Table SII. Immunohistochemistry… read more here.
Keywords: hdac6 inhibition; class hdac; hdac hdac6; inhibition inversely ... See more keywords
Abstract 6245: Selective HDAC6 inhibition by ITF3756 modifies the landscape of gene and protein expression in human monocytes: Possible identification of a specific biomarker signature
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6245
Abstract: Histone deacetylase 6 (HDAC6) modulates tumor immunogenicity through several pathways, such as the control of PD-L1 expression on tumor and on lymphoid cells. Thus, HDAC6 is a potential pharmacological target for cancer treatment. In humans,… read more here.
Keywords: signature; itf3756; identification; expression ... See more keywords
HDAC6 inhibition and deletion reduce COPD symptoms in mice and human airway epithelia
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DOI: 10.1183/13993003.congress-2020.5033
Abstract: The Histone Deacetylase 6 (HDAC6) enzyme has two deacetylase domains and is found almost exclusively in the cytoplasm. It deacetylates targets such as tubulin, cortactin, HSP90, KU70 and potentially the Treg-specific transcription factor FOXP3 but… read more here.
Keywords: hdac6 inhibition; mice human; epithelia; copd ... See more keywords
Blockade of GRP78 Translocation to the Cell Surface by HDAC6 Inhibition Suppresses Proliferation of Cholangiocarcinoma Cells
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DOI: 10.21873/anticanres.15505
Abstract: Background/Aim: HDAC6, a cytoplasmic localized deacetylase, is a positive regulator of cancer progression via modification of various substrates. We evaluated how the interaction between HDAC6 and glucose regulatory protein 78 (GRP78) affects the growth of… read more here.
Keywords: hdac6 inhibition; hdac6; grp78; cell ... See more keywords