Identification of a cancer stem cell-specific function for the histone deacetylases, HDAC1 and HDAC7, in breast and ovarian cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.337
Abstract: Tumours are comprised of a highly heterogeneous population of cells, of which only a small subset of stem-like cells possess the ability to regenerate tumours in vivo. These cancer stem cells (CSCs) represent a significant… read more here.
Keywords: csc; cancer stem; hdac7; hdac1 hdac7 ... See more keywords
HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212813120
Abstract: The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7 in macrophages is a metabolic… read more here.
Keywords: inflammatory responses; switch; hdac7; danger signals ... See more keywords
Histone Deacetylase 7 In Murine Gram-Negative Acute Lung Injury.
Sign Up to like & getrecommendations! Published in 2019 at "Shock"
DOI: 10.1097/shk.0000000000001431
Abstract: To the Editor: In the article of Kasotakis et al. ‘‘Histone deacetylase 7 inhibition in a murine model of gram-negative pneumonia-induced acute lung injury’’ recently accepted by ‘‘Shock’’ (Shock 53:344–351, 2020) (1), the authors described… read more here.
Keywords: expression; tsa; murine; hdac7 ... See more keywords
A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abl3651
Abstract: Genome-wide association studies identifying hundreds of susceptibility loci for autoimmune diseases indicate that genes active in immune cells predominantly mediate risk. However, identification and functional characterization of causal variants remain challenging. Here, we focused on… read more here.
Keywords: role; hdac7; variant; hdac7 r166h ... See more keywords
MiR-489 inhibited the development of gastric cancer via regulating HDAC7 and PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-020-01846-3
Abstract: Background Mounting evidences have displayed that the dysregulation of miRNAs plays important roles in the pathogenesis of gastric cancer (GC). The purpose of this study was to explore the biological functions and potential mechanism of… read more here.
Keywords: hdac7; gastric cancer; pi3k akt; mir 489 ... See more keywords
HDAC7 inhibits cell proliferation via NudCD1/GGH axis in triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Letters"
DOI: 10.3892/ol.2022.13619
Abstract: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer. In the absence of effective molecular markers for TNBC, there is an urgent clinical need for promising therapeutic target for TNBC. Histone deacetylases… read more here.
Keywords: cell proliferation; hdac7; ggh; nudcd1 ggh ... See more keywords