Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8.
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DOI: 10.1021/acs.jmedchem.4c00761
Abstract: HDAC8 plays crucial roles in biological processes, from gene regulation to cell motility, making it a highly desirable target for therapeutic intervention. HDAC8 also has deacetylase-independent activity which cannot be blocked by a conventional inhibitor.… read more here.
Keywords: hdac8 degrader; potent selective; highly potent; degrader ... See more keywords