HDACs regulate the differentiation of endothelial cells from human iPSCs
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3729
Abstract: Human induced pluripotent stem cells (hiPSCs) possess the potential to differentiate toward vascular cells including endothelial cells (ECs), pericytes, and smooth muscle cells. Epigenetic mechanisms including DNA methylation and histone modification play a crucial role… read more here.
Keywords: vascular progenitors; hdacs; endothelial cells; expression ... See more keywords
Osthole extracted from a citrus fruit that affects apoptosis on A549 cell line by histone deacetylasese inhibition (HDACs)
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Reports"
DOI: 10.1016/j.btre.2020.e00531
Abstract: Highlights • The grapefruit osthole act as a natural inhibitor of HDACs.• Osthole inhibited the growth of A549 cells, in a time- and concentration-dependent manner.• Ostholeinduced apoptosis and the caspase-9 was also increased by osthole… read more here.
Keywords: osthole extracted; hdacs osthole; citrus fruit; hdacs ... See more keywords
Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113824
Abstract: Hepatocellular carcinoma (HCC) is a major contributor to global cancer incidence and mortality. Many pathways are involved in the development of HCC and various proteins including mTOR and HDACs have been identified as potential drug… read more here.
Keywords: hepatocellular carcinoma; treatment; hdacs; mtor hdacs ... See more keywords
Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00321
Abstract: The acetylation status of lysine residues on histone proteins has long been attributed to a balance struck between the catalytic activity of histone acetyl transferases and histone deacetylases (HDAC). HDACs were identified as the sole… read more here.
Keywords: zinc dependent; dependent hdacs; hdacs; biology ... See more keywords
Effects of novel HDAC inhibitors on urothelial carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Epigenetics"
DOI: 10.1186/s13148-018-0531-y
Abstract: BackgroundHistone deacetylase inhibitors (HDACi) are promising anti-cancer drugs that could also be employed for urothelial carcinoma (UC) therapy. It is unclear, however, whether inhibition of all 11 zinc-dependent HDACs or of individual enzymes is more… read more here.
Keywords: cell lines; hdac4; hdacs; class iia ... See more keywords
The inhibitory effects of class I histone deacetylases on hippocampal neuroinflammatory regulation in aging mice with postoperative cognitive dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202010_23240
Abstract: OBJECTIVE Neuroinflammation in the hippocampus has been determined to contribute to postoperative cognitive dysfunction (POCD) occurrence in elderly individuals. Histone deacetylases (HDACs) have been identified as important regulators of inflammation. However, the roles of different… read more here.
Keywords: class; postoperative cognitive; hdacs; cognitive dysfunction ... See more keywords
New Insight in HDACs: Potential Therapeutic Targets for the Treatment of Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.863677
Abstract: Atherosclerosis (AS) features include progressive hardening and reduced elasticity of arteries. AS is the leading cause of morbidity and mortality. An increasing amount of evidence showed that epigenetic modifications on genes serve are a main… read more here.
Keywords: insight hdacs; hdacs; potential therapeutic; hdacs potential ... See more keywords
Effect of vorinostat on INK4 family and HDACs 1, 2, and 3 in pancreatic cancer and hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.314824
Abstract: Background and purpose: In mammalian cells, several distinct surveillance systems, named cell cycle checkpoints, can interrupt normal cell-cycle progression. The cyclin-dependent kinases are negatively regulated by proteins of cyclin-dependent kinases inhibitors comprising INK4 and Cip/Kip… read more here.
Keywords: hepatocellular carcinoma; vorinostat; effect; hdacs ... See more keywords