Raman Spectroscopic Signature Markers of Dopamine-Human Dopamine Transporter Interaction in Living Cells.
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DOI: 10.1021/acschemneuro.7b00048
Abstract: Dopamine (DA) controls many psychological and behavioral activities in the central nervous system (CNS) through interactions with the human dopamine transporter (hDAT) and dopamine receptors. The roles of DA in the function of the CNS… read more here.
Keywords: raman; dopamine; human dopamine; hdat ... See more keywords
Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter
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DOI: 10.1038/s41598-017-03771-0
Abstract: Dopamine transporter (DAT) is the target of cocaine and HIV-1 transactivator of transcription (Tat) protein. Identifying allosteric modulatory molecules with potential attenuation of cocaine and Tat binding to DAT are of great scientific and clinical… read more here.
Keywords: hdat; modulatory effects; cocaine; sri 30827 ... See more keywords
Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation
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DOI: 10.1371/journal.pone.0200085
Abstract: The human dopamine transporter (hDAT) plays a major role in dopamine homeostasis and regulation of neurotransmission by clearing dopamine from the extracellular space using secondary active transport. Dopamine is an essential monoamine chemical messenger that… read more here.
Keywords: dopamine; human dopamine; hdat; conformation ... See more keywords