Hereditary Diffuse Gastric Cancer (HDGC). An overview.
Sign Up to like & getrecommendations! Published in 2021 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2021.101820
Abstract: It is estimated that up to 10% of gastric carcinomas show familial aggregation. In contrast, around 1-3 % (approximately 33,000 yearly) are genuinely hereditary. Hereditary diffuse gastric cancer (HDGC) is a rare malignancy characterized by… read more here.
Keywords: hdgc; hereditary diffuse; gastric cancer; diffuse gastric ... See more keywords
Hereditary Diffuse Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.01.038
Abstract: Hereditary Diffuse Gastric Cancer (HDGC) is a dominantly-inherited cancer syndrome characterized by a high incidence of diffuse gastric cancer (DGC) and lobular breast cancer (LBC). HDGC is caused by germline mutations in two genes involved… read more here.
Keywords: hereditary diffuse; gastric cancer; diffuse gastric; cancer ... See more keywords
Investigation on gastric cancer susceptibility genes in Chinese early-onset diffuse gastric cancer
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz247.134
Abstract: Abstract Background Hereditary diffuse gastric cancer (HDGC) is closely related to germline mutation of CDH1. In addition, potential pathogenic germline variants in other candidate genes were detected in FGC and HDGC families. However, comprehensive genetic… read more here.
Keywords: hdgc; early onset; gastric cancer; cancer susceptibility ... See more keywords
CDH1 Germline Variants in a Tunisian Cohort with Hereditary Diffuse Gastric Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13030400
Abstract: Mutational screening of the CDH1 gene is a standard treatment for patients who fulfill Hereditary Diffuse Gastric Cancer (HDGC) testing criteria. In this framework, the classification of variants found in this gene is a crucial… read more here.
Keywords: cdh1; hereditary diffuse; diffuse gastric; gene ... See more keywords
The role of endoscopy in the management of hereditary diffuse gastric cancer syndrome
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v25.i23.2878
Abstract: Hereditary diffuse gastric cancer (HDGC) syndrome is an inherited cancer risk syndrome associated with pathogenic germline CDH1 variants. Given the high risk for developing diffuse gastric cancer, CDH1 carriers are recommended to undergo prophylactic total… read more here.
Keywords: hdgc; gastric cancer; diffuse gastric; management ... See more keywords