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   Articles with "hdm" as a keyword



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USP25 inhibits DNA damage by stabilizing BARD1 protein in a house dust mite‐induced asthmatic model in vitro and in vivo

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recommendations! Published in 2022 at "Cell Biology International"

DOI: 10.1002/cbin.11775

Abstract: House dust mites (HDM) can cause DNA double‐strand breaks in the lungs of asthmatic patients. However, the molecular mechanisms driving DNA damage and repair in HDM‐induced asthma are yet to be elucidated. Thus, in this… read more here.

Keywords: vivo; hdm; damage; dna damage ... See more keywords
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Conditioning Regimen [High-Dose Melphalan (HDM) Versus an Alternative] May Impact Response in Patients (pts) with Relapsed Multiple Myeloma (rMM) Receiving a Second Autologous Stem Cell Transplant (AutoSCT)

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recommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"

DOI: 10.1016/j.bbmt.2018.12.345

Abstract: Introduction Second AutoSCT has been demonstrated to be beneficial in pts with relapsed multiple myeloma (rMM), in clinical trials. The optimal conditioning regimen for pts who receive a second transplant has not been currently established.… read more here.

Keywords: response; rmm; hdm; second autosct ... See more keywords
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Implication of NOD-1 receptor in house dust mite (HDM)-induced asthma

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recommendations! Published in 2021 at "Revue Des Maladies Respiratoires"

DOI: 10.1016/j.rmr.2021.02.013

Abstract: Introduction NOD1 is an innate pattern-recognition sensor for Gram-negative peptidoglycan (PG) that is involved in the development of allergic asthma and signals through the kinase RIPK2. The aim of this study was to investigate the role… read more here.

Keywords: nod receptor; asthma; hdm induced; hdm ... See more keywords
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In utero exposure to genistein decreased intranasal house dust mite-induced respiratory allergy in middle-aged male B6C3F1 offspring.

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recommendations! Published in 2020 at "Toxicology letters"

DOI: 10.1016/j.toxlet.2020.07.013

Abstract: Despite many hypothesized benefits of dietary isoflavone genistein (GEN) deriving from soy-based products, questions surrounding GEN's developmental effects are increasing. To understand if in utero GEN exposure modulated postnatal respiratory allergies in the middle age,… read more here.

Keywords: exposure; gen; b6c3f1 offspring; respiratory allergy ... See more keywords
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High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma

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recommendations! Published in 2018 at "Bone Marrow Transplantation"

DOI: 10.1038/bmt.2017.208

Abstract: Single-agent high-dose melphalan (HDM, 200 mg/m2) has been the most commonly used conditioning regimen prior to autologous stem cell transplant, since its introduction in 1992. We used a more aggressive alkylator-based conditioning regimen in an attempt… read more here.

Keywords: bcnu hdm; high dose; stem cell; conditioning regimen ... See more keywords
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Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus

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recommendations! Published in 2017 at "Mucosal Immunology"

DOI: 10.1038/mi.2017.63

Abstract: CX3CL1 has been implicated in allergen-induced airway CD4+ T-lymphocyte recruitment in asthma. As epidemiological evidence supports a viral infection–allergen synergy in asthma exacerbations, we postulated that rhinovirus (RV) infection in the presence of allergen augments… read more here.

Keywords: proteases cleave; cx3cl1; cx3cl1 shedding; allergenic proteases ... See more keywords
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A 4-Week Model of House Dust Mite (HDM) Induced Allergic Airways Inflammation with Airway Remodeling

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-24574-x

Abstract: Animal models of allergic airways inflammation are useful tools in studying the pathogenesis of asthma and potential therapeutic interventions. The different allergic airways inflammation models available to date employ varying doses, frequency, duration and types… read more here.

Keywords: week; inflammation; model; airways inflammation ... See more keywords
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Extent of allergic inflammation depends on intermittent versus continuous sensitization to house dust mite

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recommendations! Published in 2017 at "Inhalation Toxicology"

DOI: 10.1080/08958378.2017.1311389

Abstract: Abstract Objective: House dust mite (HDM) exposure is used to model experimental asthma in mice. However, a direct comparison of inflammatory responses following continuous versus intermittent HDM exposure has not been reported. Therefore, we investigated… read more here.

Keywords: house dust; dust mite; inflammation; hdm ... See more keywords
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Inhalation exposure to multi-walled carbon nanotubes alters the pulmonary allergic response of mice to house dust mite allergen

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recommendations! Published in 2019 at "Inhalation Toxicology"

DOI: 10.1080/08958378.2019.1643955

Abstract: Abstract Background: Increasing evidence from rodent studies indicates that inhaled multi-walled carbon nanotubes (MWCNTs) have harmful effects on the lungs. In this study, we examined the effects of inhalation exposure to MWCNTs on allergen-induced airway… read more here.

Keywords: multi walled; exposure; mice; inhalation ... See more keywords
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Permeability of olmesartan medoxomil from lipid based and suspension formulations using an optimized HDM-PAMPA model

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recommendations! Published in 2022 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2022.2114495

Abstract: Abstract Hexadecane membrane-parallel artificial membrane permeability assay (HDM-PAMPA) is based on an artificial HDM that separates the two compartments (donor and acceptor compartment). This model is used to predict the permeability of drugs in gastrointestinal… read more here.

Keywords: hdm; permeability olmesartan; permeability; suspension ... See more keywords
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O043 Evaluation of minimal factor H therapy administered to kidneys during ex vivo normothermic perfusion as a treatment to improve ischaemia reperfusion injury

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recommendations! Published in 2023 at "British Journal of Surgery"

DOI: 10.1093/bjs/znad101.043

Abstract: Complement activation is a key mechanism of Ischaemia reperfusion injury, with the alternative pathway driving damage in particular. The main regulator of the alternative pathway is factor H. We hypothesised that homodimeric mini-factor H (HDM-FH;… read more here.

Keywords: reperfusion injury; normothermic perfusion; hdm; factor ... See more keywords