NMR Data‐Driven Docking of HDM2‐Inhibitor Complexes
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100570
Abstract: We present an automated NMR‐guided docking workflow that can be used to generate models of protein‐ligand complexes based on data from NOE NMR experiments. The first step is to generate a number of intermolecular distance… read more here.
Keywords: hdm2; data driven; docking hdm2; hdm2 inhibitor ... See more keywords
HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00340-17
Abstract: ABSTRACT Hepatitis B virus (HBV)-encoded X protein (HBx) plays a critical role in HBV-related hepatocarcinoma development. In this study, we demonstrate that HBx is specifically modified by NEDD8. We found that E3 ligase HDM2 promotes… read more here.
Keywords: hdm2 promotes; hepatitis virus; hbx; stability ... See more keywords