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   Articles with "hdp" as a keyword



Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine

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recommendations! Published in 2018 at "Diabetologia"

DOI: 10.1007/s00125-018-4707-y

Abstract: Aims/hypothesisRecent studies suggest that abnormal function in Müller glial cells plays an important role in the pathogenesis of diabetic retinopathy. This is associated with the selective accumulation of the acrolein-derived advanced lipoxidation end-product, Nε-(3-formyl-3,4-dehydropiperidino)lysine (FDP-lysine),… read more here.

Keywords: ller; diabetic retinopathy; cell; acrolein scavenging ... See more keywords

Soluble Fms-like tyrosine kinase-1 polymorphisms associated with severe-spectrum hypertensive disorders of pregnancy

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recommendations! Published in 2025 at "Archives of Gynecology and Obstetrics"

DOI: 10.1007/s00404-024-07917-0

Abstract: sFLT-1 has been implicated in the pathogenesis of HDP. We aimed to examine the role of maternal and fetal polymorphisms in risk of HDP and severe-spectrum disease. Cases of HDP (143) and controls (169) from… read more here.

Keywords: disease; increased risk; risk; severe spectrum ... See more keywords

Risks of Cause-specific Mortality in Offspring of Pregnancies Complicated by Hypertensive Disease of Pregnancy.

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recommendations! Published in 2019 at "American journal of obstetrics and gynecology"

DOI: 10.1016/j.ajog.2019.07.024

Abstract: BACKGROUND Fetal environment has a substantial influence on an individual's health throughout their life course. Animal models of hypertensive disease of pregnancy (HDP) have demonstrated adverse health outcomes among offspring exposed to HDP in utero.… read more here.

Keywords: cvd mortality; mortality; pregnancies complicated; offspring pregnancies ... See more keywords
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Coronavirus disease 2019 infection and hypertensive disorders of pregnancy

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recommendations! Published in 2021 at "American Journal of Obstetrics and Gynecology"

DOI: 10.1016/j.ajog.2021.03.001

Abstract: Objective The possible connection between COVID-19 and hypertensive disorders of pregnancy (HDP) remains unclear (1). Elucidating these outcomes is important both to better understand COVID-19 pathophysiology and to improve patient care in pregnant patients with… read more here.

Keywords: delivery; infection; hdp development; covid infection ... See more keywords

Seasonality of hypertensive disorders of pregnancy - A South Australian population study.

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recommendations! Published in 2018 at "Pregnancy hypertension"

DOI: 10.1016/j.preghy.2018.04.006

Abstract: OBJECTIVES To investigate the seasonal variation of hypertensive disorders of pregnancy (HDP) in South Australia. STUDY DESIGN Retrospective population study including all 107,846 liveborn singletons during 2007-2014 in South Australia. Seasonality in incidence of HDP… read more here.

Keywords: incidence; disorders pregnancy; hypertensive disorders; seasonality ... See more keywords

Abstracts from the 19th International Congress on Twin Studies, 26−28 September 2024

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recommendations! Published in 2025 at "Twin Research and Human Genetics"

DOI: 10.1017/thg.2025.12

Abstract: Introduction: Vitamin D plays an essential role in regulating cell prolifer-ationandapoptosisandhasbeenlinkedtoseveralobstetriccomplications. TheaimofthestudyistoassesswhethervitaminDdosageandsupple-mentationcanimproveperinataloutcomesintwinpregnancythatisat highriskperse. Materials andmethods: This retrospectivestudyincluded twinpregnanciesfollowedbytheTwinPregnancyCareUnitofSant ’ Anna Obstetric-GynecologicalHospitalinTurinbetween2020and2023.Inone groupserumvitaminDwasmeasuredinthefirsttrimesterand,ifneeded, supplementationwasadministered.InthesecondgroupvitaminDwas notmeasurednorsupplemented.First,wecomparedperinataloutcomes betweenthetwogroups.Then,weassessedwhethervitaminDstatus (insufficient,deficient,sufficient)inthefirsttrimestercouldinfluence pregnancyoutcomes. Results: Serum vitamin D was dosed (and, if… read more here.

Keywords: birth weight; twin; vitamin status; incidence ... See more keywords

Toward Dose Prediction at Point of Design.

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recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c02385

Abstract: Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis and experimental profiling. Our goal… read more here.

Keywords: point design; dose prediction; toward dose; prediction point ... See more keywords

Early-pregnancy N-terminal pro-brain natriuretic peptide level is inversely associated with hypertensive disorders of pregnancy diagnosed after 35 weeks of gestation

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-63206-5

Abstract: Hypertensive disorders of pregnancy (HDP) are among the major causes of high maternal and fetal/neonatal morbidity and mortality rates. Patients with HDP have significantly elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels at diagnosis; however, the… read more here.

Keywords: early pregnancy; probnp levels; pregnancy probnp; hdp ... See more keywords
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The potentials and challenges of left populism in Turkey: the case of the peoples’ Democratic Party (HDP)

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recommendations! Published in 2019 at "British Journal of Middle Eastern Studies"

DOI: 10.1080/13530194.2019.1634398

Abstract: ABSTRACT In spring 2015, Turkey witnessed the unexpected rise of the HDP, founded by the Kurdish Liberation Movement together with the Turkish radical left, against President Erdoğan’s authoritarian rule. In this article, I will employ… read more here.

Keywords: turkey; potentials challenges; populism; left populism ... See more keywords

#514 A klotho gene variant (rs9536314) correlates with development of hypertensive disorders of pregnancy and higher rates of miscarriage

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recommendations! Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.121

Abstract: Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal and fetal morbidity and mortality worldwide and potentially a critical threat to maternal and infant health. The incidence of HDP ranges from… read more here.

Keywords: history; hypertensive disorders; rs9536314; hdp ... See more keywords

LONG-TERM CARDIOVASCULAR OUTCOMES AFTER A PREGNANCY COMPLICATED BY HYPERTENSIVE DISORDERS

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recommendations! Published in 2024 at "Journal of Hypertension"

DOI: 10.1097/01.hjh.0001022764.21821.85

Abstract: Objective: The maternal vasculature undergoes significant adaptations during pregnancy to meet the increased metabolic demands of the developing fetus. These adaptations include increased cardiac output and blood volume, as well as reduced systemic vascular resistance… read more here.

Keywords: history; term cardiovascular; long term; pregnancy ... See more keywords