Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Letters"
DOI: 10.1007/s10529-019-02687-1
Abstract: ObjectiveHuman dental pulp-derived stem cells (hDPSCs) are becoming an attractive source for cell-based neurorestorative therapies. As such, it is important to understand the molecular mechanisms that regulate the differentiation of hDPSCs toward the neuronal fate.… read more here.
Keywords: hdpscs; notch; expression; differentiation ... See more keywords
2,4-D causes oxidative stress induction and apoptosis in human dental pulp stem cells (hDPSCs)
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-05837-0
Abstract: 2,4-Dicholorophenoxy acetic acid (2,4-D) is a worldwide used hormone herbicide. Human dental pulp stem cells (hDPSCs) as a potential source of mesenchymal stem cells provide a confident model system for the assessments of chemicals in… read more here.
Keywords: hdpscs; apoptosis; human dental; stem cells ... See more keywords
Enhancing osteogenic potential of hDPSCs by resveratrol through reducing oxidative stress via the Sirt1/Nrf2 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2037664
Abstract: Abstract Context The osteogenic potential of the human dental pulp stromal cells (hDPSCs) was reduced in the state of oxidative stress. Resveratrol (RSV) possesses numerous biological properties, including osteogenic potential, growth-promoting and antioxidant activities. Objective… read more here.
Keywords: stress; sirt1 nrf2; oxidative stress; hdpscs ... See more keywords
A laboratory study to test the responses of human dental pulp stem cells to extracts from three dental pulp capping biomaterials.
Sign Up to like & getrecommendations! Published in 2021 at "International endodontic journal"
DOI: 10.1111/iej.13495
Abstract: AIM This laboratory study aimed to investigate the effects of three endodontic biomaterials; MTA-HP, iRoot-BP-Plus and ACTIVA on the proliferation, adhesion, and osteogenic differentiation of human Dental Pulp Stem Cells (hDPSCs). METHODOLOGY The hDPSCs were… read more here.
Keywords: hdpscs; laboratory study; proliferation; dental pulp ... See more keywords
MiR-143-5p regulates the proangiogenic potential of human dental pulp stem cells by targeting HIF-1α/RORA under hypoxia: A laboratory investigation in pulp regeneration.
Sign Up to like & getrecommendations! Published in 2024 at "International endodontic journal"
DOI: 10.1111/iej.14133
Abstract: AIM Angiogenesis is a key event in the successful healing of pulp injuries, and hypoxia is the main stimulator of pulpal angiogenesis. In this study, we investigated the effect of hypoxia on the proangiogenic potential… read more here.
Keywords: hypoxia; pulp; hdpscs; mir 143 ... See more keywords
FoxO1 mediates odontoblast differentiation of hDPSCs via B cell-derived ANGPTL1 in dental caries: A laboratory investigation.
Sign Up to like & getrecommendations! Published in 2025 at "International endodontic journal"
DOI: 10.1111/iej.14206
Abstract: AIM Clinical and in vitro evidence indicates that chronic inflammatory responses initiated by dental caries can persist in the dental pulp even after treatment, necessitating the formation of reparative dentin to restore tissue homeostasis and health.… read more here.
Keywords: differentiation; foxo1; hdpscs; expression ... See more keywords
miR-342-5p inhibits odonto/osteogenic differentiation of human dental pulp stem cells via targeting Wnt7b.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14195
Abstract: OBJECTIVE Human dental pulp stem cells (hDPSCs) constitute a promising source of stem cells in tissue engineering. However, the molecular mechanism of differentiation in hDPSCs remains largely unclear. MicroRNAs (miRNAs) play crucial roles in lineage-specific… read more here.
Keywords: osteogenic differentiation; odonto osteogenic; hdpscs; mir 342 ... See more keywords
Effect of MicroRNA-138 on Tumor Necrosis Factor-Alpha-Induced Suppression of Osteogenic Differentiation of Dental Pulp Stem Cells and Underlying Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/7230167
Abstract: High doses of tumor necrosis factor-α (TNF-α) suppress osteogenic differentiation of human dental pulp stem cells (hDPSCs). In the present study, we aimed to explore the role and potential regulatory mechanism of microRNA-138 (miR-138) in… read more here.
Keywords: induced suppression; mir 138; osteogenic differentiation; hdpscs ... See more keywords
Toll-like receptor and C-type lectin receptor agonists attenuate osteogenic differentiation in human dental pulp stem cells
Sign Up to like & getrecommendations! Published in 2024 at "BMC Oral Health"
DOI: 10.1186/s12903-024-03894-7
Abstract: This study aimed to investigate the effects of various toll-like receptor (TLR) and C-type lectin receptor (CLR) ligands on osteogenic differentiation in human dental pulp stem cells (hDPSCs). hDPSCs were cultured and treated with various… read more here.
Keywords: receptor; tlr clr; toll like; hdpscs ... See more keywords
Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097708
Abstract: Odontoblastic differentiation of human dental pulp stem cells (hDPSCs) is crucial for the intricate formation and repair processes in dental pulp. Until now, the literature is not able to demonstrate the role of ubiquitination in… read more here.
Keywords: dental pulp; odontoblastic differentiation; hdpscs; human dental ... See more keywords
Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide-co-caprolactone) Scaffold
Sign Up to like & getrecommendations! Published in 2022 at "Materials"
DOI: 10.3390/ma15051900
Abstract: Poly(l-lactide-co-caprolactone) (PLCL) electrospun scaffolds with seeded stem cells have drawn great interest in tissue engineering. This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrolytically-modified PLCL nanofiber scaffold.… read more here.
Keywords: dental pulp; hdpscs; pulp stem; stem cells ... See more keywords