Articles with "hdr efficiency" as a keyword



Photo from wikipedia

Homology-directed repair in mouse cells increased by CasRx-mediated knockdown or co-expressing Kaposi’s sarcoma-associated herpesvirus ORF52

Sign Up to like & get
recommendations!
Published in 2019 at "Bioscience Reports"

DOI: 10.1042/bsr20191914

Abstract: Abstract Precise genome editing with directed base insertion or targeted point mutations can be achieved by CRISPR/Cas9-mediated homology-directed repair (HDR) and is of great significance in clinical disease therapy. However, HDR efficiency, compared with non-homologous… read more here.

Keywords: sarcoma associated; kaposi sarcoma; associated herpesvirus; directed repair ... See more keywords
Photo from wikipedia

Decorating chromatin for enhanced genome editing using CRISPR-Cas9

Sign Up to like & get
recommendations!
Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2204259119

Abstract: CRISPR-associated (Cas) enzymes have revolutionized biology by enabling RNA-guided genome editing. Homology-directed repair (HDR) in the presence of donor templates is currently the most versatile method to introduce precise edits following CRISPR-Cas-induced double-stranded DNA cuts,… read more here.

Keywords: genome editing; repair; crispr; hdr efficiency ... See more keywords