The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05527-0
Abstract: Objective To determine the diagnostic value and clinical significance of serum HE4 levels in differentiating between benign and malignant ovarian disease in patients with elevated CA125 levels. Methods The levels and positive expression rate of… read more here.
Keywords: ovarian disease; elevated ca125; serum he4; diagnostic value ... See more keywords
Ovarian cancer recurrence and early detection: may HE4 play a key role in this open challenge? A systematic review of literature
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-1026-y
Abstract: Abstract Despite the improvement in overall survival for ovarian cancer (OC) patients, a fraction of patients with advanced-stage disease fails to respond to primary therapy and relapses in 70% of cases. For this reason, new… read more here.
Keywords: recurrence; review; ovarian cancer; role ... See more keywords
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.015
Abstract: Human epididymis protein 4 (HE4) is a glycoprotein secreted by epithelial ovarian cancer (EOC) cells and is a novel and specific biomarker for diagnosing and prognosing EOC. Previous studies have shown that overexpression of HE4… read more here.
Keywords: epididymis protein; human epididymis; he4; anti he4 ... See more keywords
Human epididymis protein 4 is associated with severity and poor prognosis of connective tissue disease-associated interstitial lung disease with usual interstitial pneumonia pattern.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108704
Abstract: BACKGROUND Overexpression of human epididymis protein 4 (HE4) was previously described in idiopathic pulmonary fibrosis (IPF), but whether serum HE4 can be considered as a potential biomarker in connective tissue disease-associated interstitial lung disease (CTD-ILD)… read more here.
Keywords: uip ctd; lung; human epididymis; disease ... See more keywords
Comparison of two immunoassays for the measurement of serum HE4 for ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Practical Laboratory Medicine"
DOI: 10.1016/j.plabm.2021.e00235
Abstract: Introduction The use of Human Epididymis Protein 4 (HE4) as a biomarker for ovarian cancer is gaining traction, providing the impetus for development of a high throughput automated HE4 assay that is comparable to the… read more here.
Keywords: serum; serum he4; ovarian cancer; measurement serum ... See more keywords
Electrochemical immunomagnetic assay as biosensing strategy for determination of ovarian cancer antigen HE4 in human serum.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2020.120991
Abstract: Prompt cancer diagnosis and treatment represent fundamental aspects to significantly improve patient survival rate. Human epididymis protein 4 (HE4) has recently been identified as promising single serum biomarker of epithelial ovarian cancer with improved diagnostic… read more here.
Keywords: strategy; determination; serum; ovarian cancer ... See more keywords
Sensitive Detection of the Human Epididymis Protein-4 (HE4) Ovarian Cancer Biomarker through a Sandwich-Type Immunoassay Method with Laser-Induced Breakdown Spectroscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00551
Abstract: Detection of cancer before the appearance of any symptoms is crucial for successful treatment. Early detection is, however, very challenging, particularly for the types of cancer with few or no symptoms at early stages, such… read more here.
Keywords: biomarker; spectroscopy; chemistry; detection ... See more keywords
Human epididymis protein 4-annexin II binding promotes aberrant epithelial-fibroblast crosstalk in pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07529-7
Abstract: Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here,… read more here.
Keywords: aberrant epithelial; he4; fibroblast; crosstalk ... See more keywords
Clinical utility of human epididymis protein 4
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2025.2512467
Abstract: Abstract This review comprehensively elucidates the current clinical applications of human epididymis protein 4 (HE4) in various systemic diseases. Initially discovered in 1991 and linked to sperm maturation, HE4 has since been recognized for its… read more here.
Keywords: human epididymis; clinical utility; epididymis protein; he4 ... See more keywords
Serum Human Epididymis Protein 4 Combined with Carbohydrate Antigen 125 for Endometrial Carcinoma Diagnosis: A Meta-Analysis and Systematic Review.
Sign Up to like & getrecommendations! Published in 2019 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2019.0046
Abstract: Objective: To evaluate the overall diagnostic value of human epididymis protein 4 (HE4) combined with carbohydrate antigen 125 (CA125) in endometrial carcinoma (EC) based on a meta-analysis of all eligible studies. Methods: The PubMed, Cochrane,… read more here.
Keywords: he4 combined; combined ca125; meta analysis; he4 ... See more keywords
P-296 The relationship between serum HE4 and ultrasound findings of adenomyosis in infertility patients and its correlation with implantation and pregnancy outcomes in those undergoing IVF-ET
Sign Up to like & getrecommendations! Published in 2024 at "Human Reproduction"
DOI: 10.1093/humrep/deae108.663
Abstract: Are there correlations between HE4 levels and the presence of ultrasonographic findings of adenomyosis in infertile women, and how does this relationship effect pregnancy outcomes? The presence of subendometrial linear lines as marker of endo-myometrial… read more here.
Keywords: adenomyosis; he4; implantation; he4 levels ... See more keywords