The differential diagnostic value and clinical significance of serum HE4 in ovarian disease with elevated CA125
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-020-05527-0
Abstract: Objective To determine the diagnostic value and clinical significance of serum HE4 levels in differentiating between benign and malignant ovarian disease in patients with elevated CA125 levels. Methods The levels and positive expression rate of… read more here.
Keywords: ovarian disease; elevated ca125; serum he4; diagnostic value ... See more keywords
Ovarian cancer recurrence and early detection: may HE4 play a key role in this open challenge? A systematic review of literature
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-1026-y
Abstract: Abstract Despite the improvement in overall survival for ovarian cancer (OC) patients, a fraction of patients with advanced-stage disease fails to respond to primary therapy and relapses in 70% of cases. For this reason, new… read more here.
Keywords: recurrence; review; ovarian cancer; role ... See more keywords
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.015
Abstract: Human epididymis protein 4 (HE4) is a glycoprotein secreted by epithelial ovarian cancer (EOC) cells and is a novel and specific biomarker for diagnosing and prognosing EOC. Previous studies have shown that overexpression of HE4… read more here.
Keywords: epididymis protein; human epididymis; he4; anti he4 ... See more keywords
Human epididymis protein 4 is associated with severity and poor prognosis of connective tissue disease-associated interstitial lung disease with usual interstitial pneumonia pattern.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2022.108704
Abstract: BACKGROUND Overexpression of human epididymis protein 4 (HE4) was previously described in idiopathic pulmonary fibrosis (IPF), but whether serum HE4 can be considered as a potential biomarker in connective tissue disease-associated interstitial lung disease (CTD-ILD)… read more here.
Keywords: uip ctd; lung; human epididymis; disease ... See more keywords
Comparison of two immunoassays for the measurement of serum HE4 for ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Practical Laboratory Medicine"
DOI: 10.1016/j.plabm.2021.e00235
Abstract: Introduction The use of Human Epididymis Protein 4 (HE4) as a biomarker for ovarian cancer is gaining traction, providing the impetus for development of a high throughput automated HE4 assay that is comparable to the… read more here.
Keywords: serum; serum he4; ovarian cancer; measurement serum ... See more keywords
Electrochemical immunomagnetic assay as biosensing strategy for determination of ovarian cancer antigen HE4 in human serum.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2020.120991
Abstract: Prompt cancer diagnosis and treatment represent fundamental aspects to significantly improve patient survival rate. Human epididymis protein 4 (HE4) has recently been identified as promising single serum biomarker of epithelial ovarian cancer with improved diagnostic… read more here.
Keywords: strategy; determination; serum; ovarian cancer ... See more keywords
Sensitive Detection of the Human Epididymis Protein-4 (HE4) Ovarian Cancer Biomarker through a Sandwich-Type Immunoassay Method with Laser-Induced Breakdown Spectroscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00551
Abstract: Detection of cancer before the appearance of any symptoms is crucial for successful treatment. Early detection is, however, very challenging, particularly for the types of cancer with few or no symptoms at early stages, such… read more here.
Keywords: biomarker; spectroscopy; chemistry; detection ... See more keywords
Serum Human Epididymis Protein 4 Combined with Carbohydrate Antigen 125 for Endometrial Carcinoma Diagnosis: A Meta-Analysis and Systematic Review.
Sign Up to like & getrecommendations! Published in 2019 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2019.0046
Abstract: Objective: To evaluate the overall diagnostic value of human epididymis protein 4 (HE4) combined with carbohydrate antigen 125 (CA125) in endometrial carcinoma (EC) based on a meta-analysis of all eligible studies. Methods: The PubMed, Cochrane,… read more here.
Keywords: he4 combined; combined ca125; meta analysis; he4 ... See more keywords
Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level: a prospective cross-sectional study in healthy Chinese people
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000785
Abstract: Abstract Background: Human epididymis secretory protein 4 (HE4) is a new ovarian cancer biomarker. The factors influencing HE4 levels are not clear, and the reference data in China are limited. Here, we aim to evaluate… read more here.
Keywords: post menopausal; menopausal; age; menopausal status ... See more keywords
Diagnostic performance of CA125, HE4, ROMA, and CPH‐I in identifying primary ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15540
Abstract: To evaluate the ability of carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), risk of ovarian malignancy algorithm (ROMA), and Copenhagen Index (CPH‐I) to identify primary ovarian cancer (OC) from borderline and benign ovarian… read more here.
Keywords: ca125; ovarian cancer; primary ovarian; roma ... See more keywords
416 HE 4 protein concentration in women with endometrial cancer and uterine fibroids
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-igcs.416
Abstract: Endometrial cancer is the most common malignant tumours of the female sexual organ, its incidence has been on the rise for many years. To date, there is no reliable diagnostic marker of this disease. The… read more here.
Keywords: protein concentration; endometrial cancer; women endometrial; cancer ... See more keywords