Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.08.006
Abstract: Electron transfer between respiratory complexes drives transmembrane proton translocation, which powers ATP synthesis and membrane transport. The homodimeric respiratory complex III (CIII2) oxidizes ubiquinol to ubiquinone, transferring electrons to cytochrome c and translocating protons through… read more here.
Keywords: head; rieske head; complex iii; head domain ... See more keywords
Crystal structures of Uso1 membrane tether reveal an alternative conformation in the globular head domain
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66480-1
Abstract: Membrane tethers play a critical role in organizing the complex molecular architecture of eukaryotic cells. Uso1 (yeast homolog of human p115) is essential for tethering in vesicle transport from ER to Golgi and interacts with… read more here.
Keywords: structures uso1; head domain; crystal structures; domain ... See more keywords
Hyper-swivel head domain motions are required for complete mRNA-tRNA translocation and ribosome resetting.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac597
Abstract: Translocation of messenger RNA (mRNA) and transfer RNA (tRNA) substrates through the ribosome during protein synthesis, an exemplar of directional molecular movement in biology, entails a complex interplay of conformational, compositional, and chemical changes. The… read more here.
Keywords: ribosome resetting; translocation; hyper swivel; protein synthesis ... See more keywords
The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering
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DOI: 10.1242/jcs.239202
Abstract: ABSTRACT Integrin activation and clustering by talin are early steps of cell adhesion. Membrane-bound talin head domain and kindlin bind to the β integrin cytoplasmic tail, cooperating to activate the heterodimeric integrin, and the talin… read more here.
Keywords: talin head; head domain; head; integrin ... See more keywords
Vaccine Efficacy of Self-Assembled Multimeric Protein Scaffold Particles Displaying the Glycoprotein Gn Head Domain of Rift Valley Fever Virus
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DOI: 10.3390/vaccines9030301
Abstract: Compared to free antigens, antigens immobilized on scaffolds, such as nanoparticles, generally show improved immunogenicity. Conventionally, antigens are conjugated to scaffolds through genetic fusion or chemical conjugation, which may result in impaired assembly or heterogeneous… read more here.
Keywords: protein scaffold; rift valley; head domain; multimeric protein ... See more keywords