Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid β-protein fibrillation and cytotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers of Chemical Science and Engineering"
DOI: 10.1007/s11705-017-1687-2
Abstract: Amyloid-β (Aβ) protein aggregation is the main hallmark of Alzheimer’s disease (AD). Inhibition of Aβ fibrillation is thus a promising therapeutic approach to the prevention and treatment of AD. Recently, we designed a heptapeptide inhibitor,… read more here.
Keywords: fibrillation; cyclization; head tail; amyloid protein ... See more keywords
On the Magnetic Coupling and Spin Crossover Behavior in Complexes Containing the Head-to-Tail [FeII2(μ-SCN)2] Bridging Unit: A Magnetostructural Experimental and Theoretical Study.
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b03082
Abstract: A new dinuclear complex [{Fe(tpc-OBn)(NCS)(μ-NCS)}2] (1) based on the tripodal tpc-OBn ligand (tpc-OBn = tris(2-pyridyl)benzyloxymethane), containing bridging μ-κN:κS-SCN and terminal κN-SCN thiocyanate ligands, has been prepared and characterized by single crystal X-ray diffraction, magnetic studies,… read more here.
Keywords: magnetic coupling; scn bridging; spin crossover; head tail ... See more keywords
Head and Tail Oxidized Terpenoid Esters from Androconia of Heliconius erato Butterflies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00300
Abstract: Heliconius erato is a neotropical butterfly species that is part of a complex mimicry ring, with colorful wing patterns. For intraspecific communication, males use pheromones that are released from two different scent-emitting structures. Scent glands… read more here.
Keywords: head tail; tail oxidized; oxidized terpenoid; heliconius erato ... See more keywords
Post-Assembly Modification of Head-to-Tail Cyclic Peptides by Methionine-Directed β-C(sp3)-H Arylation.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02253
Abstract: Peptide modification by C(sp3)-H functionalization of internal residues remains a major challenge due to the inhibitory effect of peptide bonds. In this work, we developed a methionine-directed β-C(sp3)-H arylation method for internal alanine functionalization. By… read more here.
Keywords: methionine directed; directed sp3; head; head tail ... See more keywords
Enhanced Excited-State Hydricity of Pd-H Allows for Unusual Head-to-Tail Hydroalkenylation of Alkenes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c02410
Abstract: Photoinduced enhancement of hydricity of palladium hydride species enables unprecedented hydride addition-like ("hydridic") hydropalladation of electron-deficient alkenes, which allows for chemoselective head-to-tail cross-hydroalkenylation of electron-deficient and electron-rich alkenes. This mild and general protocol works with… read more here.
Keywords: head tail; hydroalkenylation; hydricity; enhanced excited ... See more keywords
Asymmetric Silica Nanoparticles with Tunable Head-Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.6b12622
Abstract: Asymmetric mesoporous silica nanoparticles (MSNs) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous), and the tail has dendritic large pores. The tail length and tail coverage… read more here.
Keywords: head; silica nanoparticles; head tail; tail structures ... See more keywords
Interactions regulating the head-to-tail directed assembly of biological Janus rods.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01566f
Abstract: The directed, head-to-tail self-assembly of microtubule filaments may be generalized in the context of Janus colloidal rods. Specifically, their assembly at the tens of micron-length scale involves a careful balance between long-range electrostatic repulsion and… read more here.
Keywords: interactions regulating; janus; directed assembly; head tail ... See more keywords
Molecular salt crystals with bis(head-to-tail) interionic complementary assembly for efficient organic THz generators
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Materials Chemistry C"
DOI: 10.1039/d0tc02225j
Abstract: We report new organic nonlinear optical salt crystals comprising bis(head-to-tail) complementary cation–anion assembly that results in extremely efficient THz wave generation. In the new salt crystals, each of the ends of the molecular anion, 4-(trifluoromethyl)benzenesulfonate,… read more here.
Keywords: salt crystals; bis head; thz; head tail ... See more keywords
Head-tail-head neural wiring underlies gut fat storage in Caenorhabditis elegans temperature acclimation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203121119
Abstract: Significance Animals maintain the ability to survive and reproduce by acclimating to temperature. The nematode Caenorhabditis elegans possesses experience-dependent temperature acclimation. Here, we revealed that a head-tail-head neural circuit regulated gut fat storage, which was… read more here.
Keywords: head; tail head; head tail; temperature acclimation ... See more keywords
SUN5 Interacting With Nesprin3 Plays an Essential Role in Sperm Head-to-Tail Linkage: Research on Sun5 Gene Knockout Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.684826
Abstract: Acephalic spermatozoa syndrome is a rare genetic and reproductive disease. Recent studies have shown that approximately 33–47% of patients with acephalic spermatozoa syndrome have SUN5 mutations, but the molecular mechanism underlying this phenomenon has not… read more here.
Keywords: sun5; head tail; mice; tail ... See more keywords