Efficacy of three filgrastim‐intended copies for hematopoietic stem cell mobilization in healthy adult and pediatric donors in Mexico
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21707
Abstract: The use of filgrastim biosimilars for healthy adult and pediatric donor mobilization in hematopoietic stem cell transplantation has been met with increased safety and efficacy concerns in contrast to generic small molecule drugs. In Mexico,… read more here.
Keywords: healthy adult; filgrastim intended; stem cell; intended copies ... See more keywords
Effects of strong and moderate CYP3A4 inducers on the pharmacokinetics of fedratinib in healthy adult participants
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04292-4
Abstract: Fedratinib is an oral and selective Janus kinase 2 inhibitor that is indicated for treatment of adults with intermediate-2 or high-risk primary or secondary myelofibrosis. Fedratinib is metabolized by cytochrome P450s (CYPs), primarily CYP3A4. The… read more here.
Keywords: moderate cyp3a4; healthy adult; strong moderate; rifampin ... See more keywords
Intrapulmonary pharmacokinetics of cefiderocol, a novel siderophore cephalosporin, in healthy adult subjects
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz123
Abstract: Abstract Background Cefiderocol, a novel siderophore cephalosporin, has shown potent activity against Gram-negative bacteria, including MDR pathogens. Cefiderocol is under clinical investigation for the treatment of serious Gram-negative infections including nosocomial pneumonia. Objectives This study… read more here.
Keywords: healthy adult; novel siderophore; siderophore cephalosporin; cefiderocol novel ... See more keywords
Effects of a Milk Oligosaccharide Biosimilar on Fecal Characteristics, Microbiota, and Bile Acid, Calprotectin, and Immunoglobulin Concentrations of Healthy Adult Dogs Treated with Metronidazole.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of animal science"
DOI: 10.1093/jas/skad011
Abstract: In recent dog and cat experiments, a novel milk oligosaccharide biosimilar (GNU100) positively modulated fecal microbiota and metabolite profiles, suggesting benefits to gastrointestinal health. The objective of this study was to investigate the effects of… read more here.
Keywords: dogs treated; oligosaccharide biosimilar; microbiota; milk oligosaccharide ... See more keywords
Population pharmacokinetics of raxibacumab in healthy adult subjects.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.14894
Abstract: AIM Raxibacumab is a fully humanized monoclonal antibody that blocks the interaction of Bacillus anthracis toxins, thereby protecting target cells from its effects. Raxibacumab is approved in the USA for the treatment of adults and… read more here.
Keywords: healthy adult; pharmacokinetics raxibacumab; raxibacumab; population pharmacokinetics ... See more keywords
Relative bioavailability of delamanid 50 mg tablets dispersed in water in healthy adult volunteers.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15672
Abstract: AIM Delamanid is a novel drug to treat of drug-resistant tuberculosis, manufactured as 50 mg solid and 25 mg dispersible tablets. We evaluated the effects of dispersing the 50 mg tablet, focusing on the relative… read more here.
Keywords: relative bioavailability; healthy adult; delamanid tablets; bioavailability ... See more keywords
Comparison of point-of-care NOVA CCX blood gas analyzer to laboratory analyzer in a population of healthy adult cats.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of veterinary emergency and critical care"
DOI: 10.1111/vec.13155
Abstract: OBJECTIVE To compare the level of agreement of measurement of analytes (sodium, chloride, potassium, urea nitrogen [UN], creatinine, glucose) in a population of healthy adult cats between the point-of-care (POC) analyzer and laboratory analyzer. To… read more here.
Keywords: analyzer laboratory; mmol; healthy adult; care ... See more keywords
Single Ascending-Dose Study To Evaluate the Safety, Tolerability, and Pharmacokinetics of Sutezolid in Healthy Adult Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02108-21
Abstract: The primary objective of the study was to evaluate the safety and tolerability of single oral doses of sutezolid tablets administered under fasting conditions in healthy adult subjects. The secondary objective was to determine the… read more here.
Keywords: study evaluate; evaluate safety; healthy adult; adult subjects ... See more keywords
Optical Coherence Tomography Angiography in Healthy Adult Subjects: Normative Values, Frequency, and Impact of Artifacts
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/7286252
Abstract: Aim This cross-sectional study is aimed at identifying normative ocular coherence tomography angiography (OCTA) values in a cohort of healthy adult Jordanian individuals and assessing the prevalence of different image artifacts and their impact on… read more here.
Keywords: density; vascular density; healthy adult; tomography angiography ... See more keywords
Short-term postprandial changes in select serum biochemistry analytes in healthy adult cats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x221121929
Abstract: Objectives The aim of this study was to evaluate the magnitude, duration and significance of postprandial changes to select serum biochemistry analytes in healthy adult cats in the 12 h period after a meal. Methods Nine… read more here.
Keywords: postprandial changes; healthy adult; hour; adult cats ... See more keywords
WHOLE BLOOD THROMBOELASTOGRAPHY IN HEALTHY ADULT CAMELIDS (VICUGNA PACOS AND CAMELUS DROMEDARIUS)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Zoo and Wildlife Medicine"
DOI: 10.1638/2021-0033
Abstract: Abstract: Thromboelastography (TEG) provides a global assessment of hemostasis and fibrinolysis and has broad applications to identify and monitor coagulation dysfunction in veterinary patients. Although alpacas are susceptible to a wide variety of coagulopathies, the… read more here.
Keywords: teg; adult; activated teg; healthy adult ... See more keywords