Predictors of changes after reasoning training in healthy adults
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1861
Abstract: To investigate predictors of performance changes and their time course in healthy older adults. read more here.
Keywords: healthy adults; predictors changes; changes reasoning; reasoning training ... See more keywords
Pharmacokinetics and Safety of Vibegron 75 mg Administered as an Intact or Crushed Tablet in Healthy Adults
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1169
Abstract: Oral pharmacotherapy for overactive bladder, a condition that increases with age, includes anticholinergics and β3‐adrenergic receptor agonists. Older adults, including those with dysphagia, may have difficulty swallowing tablets. In this phase 1 study in healthy… read more here.
Keywords: vibegron; pharmacokinetics safety; tablet; healthy adults ... See more keywords
Effect of Multiple Doses of Sparsentan on the Single‐Dose Pharmacokinetics of Dapagliflozin: An Open‐Label Drug–Drug Interaction Study in Healthy Adults
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1231
Abstract: Sparsentan is a single‐molecule dual antagonist of the endothelin type A receptor and angiotensin II type 1 receptor under investigation for the treatment of focal segmental glomerulosclerosis and immunoglobulin A nephropathy. Dapagliflozin, a sodium‐glucose cotransporter… read more here.
Keywords: effect; sparsentan single; healthy adults; drug ... See more keywords
Safety, Tolerability, and Pharmacokinetics of 3 g of Ceftolozane/Tazobactam in Healthy Adults: A Randomized, Placebo‐Controlled, Multiple‐Dose Study
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.429
Abstract: Ceftolozane/tazobactam is an antibacterial approved at 1.5 g (1g/0.5 g) every 8 hours (q8h); higher doses may provide additional benefits in difficult‐to‐treat infections. We conducted a phase I trial in healthy adults evaluating safety, tolerability,… read more here.
Keywords: day; healthy adults; ceftolozane tazobactam; safety tolerability ... See more keywords
A Phase 1 Study of Intravenous Plazomicin in Healthy Adults to Assess Potential Effects on the QT/QTc Interval, Safety, and Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.653
Abstract: Plazomicin is an aminoglycoside with in vitro activity against multidrug‐resistant Enterobacteriaceae. A phase 1, randomized, double‐blind, crossover study assessed the potential effects of plazomicin on cardiac repolarization (NCT01514929). Fifty‐six healthy adults (24 men, 32 women)… read more here.
Keywords: phase; healthy adults; qtc interval; effect ... See more keywords
Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1696
Abstract: Ubrogepant is a novel, oral calcitonin gene–related peptide receptor antagonist currently under US Food and Drug Administration (FDA) review for the acute treatment of migraine attacks. This double‐blind, four‐period crossover study compared the cardiac repolarization… read more here.
Keywords: single therapeutic; cardiac repolarization; healthy adults; therapeutic supratherapeutic ... See more keywords
Anticipating control over aversive stimuli is mediated by the medial prefrontal cortex: An fMRI study with healthy adults
Sign Up to like & getrecommendations! Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25549
Abstract: The anticipation of control over aversive events in life is relevant for our mental health. Insights on the underlying neural mechanisms remain limited. We developed a new functional magnetic resonance imaging (fMRI) task that uses… read more here.
Keywords: healthy adults; control aversive; cortex; control ... See more keywords
Distribution of urinary N‐acetyl‐beta‐D‐glucosaminidase and the establishment of reference intervals in healthy adults
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23748
Abstract: Urinary N‐acetyl‐beta‐D‐glucosaminidase (NAG) plays an important role in the early diagnosis and progression of diseases related to renal tubular injury. We detected the urinary NAG concentration, assessed the preliminary statistics of its distribution, and established… read more here.
Keywords: healthy adults; reference intervals; beta glucosaminidase; acetyl beta ... See more keywords
Correlations between left atrial volumes and strains in healthy adults: Detailed analysis from the three‐dimensional speckle‐tracking echocardiographic MAGYAR‐Healthy Study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Ultrasound"
DOI: 10.1002/jcu.23009
Abstract: Little is known about the relationship between left atrium (LA) volumes and contractility features along the cardiac cycle. The present study aimed to assess, by three‐dimensional speckle‐tracking echocardiography (3DSTE), correlations between LA volumes, volume‐based functional… read more here.
Keywords: three dimensional; healthy adults; dimensional speckle; study ... See more keywords
High–Frame Rate Vector Flow Imaging of the Carotid Bifurcation in Healthy Adults: Comparison With Color Doppler Imaging
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.14579
Abstract: To evaluate the carotid bifurcation in healthy adults using a commercial system equipped with high–frame rate vector flow imaging (VFI) based on the plane wave and to compare VFI with color Doppler imaging. read more here.
Keywords: carotid bifurcation; healthy adults; bifurcation healthy; frame rate ... See more keywords
Acute prazosin administration does not reduce stressor reactivity in healthy adults
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05297-x
Abstract: RationaleNorepinephrine plays a critical role in the stress response. Clarifying the psychopharmacological effects of norepinephrine manipulation on stress reactivity in humans has important implications for basic neuroscience and treatment of stress-related psychiatric disorders, such as… read more here.
Keywords: administration; healthy adults; reactivity healthy; reactivity ... See more keywords