Association between GPx‐1 polymorphisms and personality traits in healthy Chinese‐Han subjects
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DOI: 10.1002/brb3.1897
Abstract: Cloninger developed the three‐dimensional personality theory and Tridimensional Personality Questionnaire (TPQ), which shows that some dimensions of personality traits are heritable and related to neurotransmitters including dopamine. glutathione peroxidase 1 (GPx1) plays an important role… read more here.
Keywords: healthy chinese; chinese han; personality traits; han subjects ... See more keywords
Pharmacokinetics and Bioequivalence Evaluation of 2 Olmesartan Medoxomil and Amlodipine Besylate Fixed‐Dose Combination Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1086
Abstract: Combined antihypertensive drugs have become the basic method of treating hypertension. Olmesartan and amlodipine, as representative drugs of angiotensin receptor blockers and calcium channel blockers, were developed as a compound formulation for antihypertensive treatment. The… read more here.
Keywords: time; fasting fed; fed conditions; bioequivalence ... See more keywords
Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor‐α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects
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DOI: 10.1002/cpdd.1091
Abstract: This study aimed to compare the pharmacokinetics, safety, and immunogenicity of the prefilled syringe (PFS) with lyophilized (LYO) recombinant human tumor necrosis factor‐α receptor II:lgG Fc fusion protein (rhTNFR:Fc) in healthy Chinese male subjects. A… read more here.
Keywords: safety; chinese male; healthy chinese; immunogenicity ... See more keywords
Pharmacokinetics and Bioequivalence of a Generic and a Branded Pazopanib Tablet in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1096
Abstract: This study aimed to evaluate the bioequivalence of two pazopanib tablet formulations in healthy Chinese subjects. A randomized, open‐label, single‐dose, two‐period, two‐sequence, crossover study was conducted under fasting conditions. A total of 32 eligible subjects… read more here.
Keywords: pazopanib tablet; chinese subjects; tablet; generic branded ... See more keywords
Pharmacokinetics and Bioequivalence of 2 Oral Formulations of Domperidone After Single‐Dose Administration in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1097
Abstract: To evaluate the pharmacokinetic properties and bioequivalence of 2 oral formulations of domperidone in healthy Chinese subjects, a randomized, open‐label, 2‐way crossover study was conducted under fasting and fed states. All 96 healthy subjects were… read more here.
Keywords: time; bioequivalence oral; domperidone; formulations domperidone ... See more keywords
The Safety, Toleration, and Pharmacokinetics of Two Intravenous Voriconazole Formulations in Healthy Chinese Volunteers After Increasing Dose Administrations
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DOI: 10.1002/cpdd.1126
Abstract: Sulfobutyl ether‐beta‐cyclodextrin sodium salt contained in the marketed intravenous voriconazole injection as a solubilizer may cause harmful accumulations. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PKs) of two intravenous voriconazole formulations containing… read more here.
Keywords: safety; two intravenous; chinese volunteers; dose administrations ... See more keywords
Pharmacokinetic and Safety Comparison of 2 Afatinib Dimaleate Tablets in Healthy Chinese Volunteers Under Fasted Conditions: A Randomized, Open‐Label, 2‐Period, Single‐Dose Crossover Study
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DOI: 10.1002/cpdd.1134
Abstract: In this bioequivalence study, we aimed to evaluate the bioequivalence of test (T) and reference (R) afatinib dimaleate tablets in healthy Chinese subjects under fasted conditions. This was a randomized, open‐label, 2‐period, single‐dose, crossover study.… read more here.
Keywords: period; crossover; afatinib dimaleate; fasted conditions ... See more keywords
Pharmacokinetics and Bioequivalence of 2 Safinamide Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions
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DOI: 10.1002/cpdd.1157
Abstract: To assess the bioequivalence of a generic safinamide tablet (test) vs a brand‐name safinamide tablet (reference) and effects of food on the pharmacokinetics of safinamide in healthy Chinese subjects, a single‐center, single‐dose, randomized, open‐label, 2‐preparation,… read more here.
Keywords: time; fasting fed; chinese volunteers; fed conditions ... See more keywords
Pharmacokinetic and Bioequivalence Study of Eldecalcitol Soft Capsules in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1159
Abstract: Eldecalcitol is a novel active vitamin D3 1,25(OH)2D3 derivative used in the treatment of osteoporosis. To investigate and compare the pharmacokinetic and bioequivalent profiles of two eldecalcitol soft capsule formulations at a single dose of… read more here.
Keywords: chinese subjects; fed conditions; eldecalcitol soft; soft capsules ... See more keywords
Pharmacokinetic and Bioequivalent Study of Potassium Chloride Sustained‐Release Tablet Under Different Dietary Conditions in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1180
Abstract: Potassium (K+) is an endogenous substance that is an essential dietary component. However, the interaction between dietary arrangements and specific effects of dietary K+ intake in bioequivalence studies remains unclear. To investigate the influence of… read more here.
Keywords: dietary conditions; potassium chloride; sustained release; healthy chinese ... See more keywords
A Single‐dose, Two‐Period Crossover Bioequivalence Study Comparing Two Liraglutide Formulations in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.1187
Abstract: Liraglutide, a glucagon‐like peptide 1 receptor agonist, is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes. The original liraglutide products are costly, which limits patient… read more here.
Keywords: single dose; chinese subjects; liraglutide formulations; bioequivalence ... See more keywords