Pharmacokinetics, Safety, and Tolerability of Brivaracetam in Healthy Elderly Participants.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1264
Abstract: The pharmacokinetics, metabolism, safety, and tolerability of the antiseizure medication brivaracetam (BRV) were characterized in 16 healthy elderly participants (8 men/8 women) aged 65-78 years who received a single 200-mg oral dose of BRV on day… read more here.
Keywords: brivaracetam; healthy elderly; safety tolerability; elderly participants ... See more keywords
Biperiden Challenge Model in Healthy Elderly as Proof‐of‐Pharmacology Tool: A Randomized, Placebo‐Controlled Trial
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1913
Abstract: Selective M1 muscarinic acetylcholine receptor (mAChR) agonists are being developed as symptomatic treatment for neurodegenerative and neuropsychiatric disorders that lead to cognitive dysfunction. Demonstrating cognition‐enhancing effects in early‐phase clinical development in healthy subjects is difficult.… read more here.
Keywords: healthy elderly; biperiden; randomized placebo; pharmacology ... See more keywords
Urinary liver‐type fatty acid‐binding protein in clinically healthy elderly cats: Evaluation of its potential to detect IRIS stage 1 chronic kidney disease and borderline proteinuria
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.1003
Abstract: Abstract Background Urinary liver‐type fatty acid‐binding protein (uL‐FABP) is a promising biomarker to detect early chronic kidney disease (CKD) in cats. Few healthy cats show increased uL‐FABP for unknown reasons. Objectives The objective of this… read more here.
Keywords: borderline proteinuria; healthy elderly; stage; iris stage ... See more keywords
Neuronal correlates of the visual-spatial processing measured with functional near-infrared spectroscopy in healthy elderly individuals
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychologia"
DOI: 10.1016/j.neuropsychologia.2020.107650
Abstract: Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) are a globally rising issue. It is necessary to detect such diseases early to find strategies for prevention. Typically, patients with MCI or AD show deviant neuronal… read more here.
Keywords: visual spatial; healthy elderly; functional near; spectroscopy ... See more keywords
Glutamine + glutamate level predicts the magnitude of microstructural organization in the gray matter in the healthy elderly
Sign Up to like & getrecommendations! Published in 2019 at "International Psychogeriatrics"
DOI: 10.1017/s1041610219001418
Abstract: ABSTRACT Background: Diffusion tensor imaging (DTI), which is a technique for measuring the degree and direction of movement of water molecules in tissue, has been widely used to noninvasively assess white matter (WM) or gray… read more here.
Keywords: healthy elderly; gray matter; glutamine glutamate; microstructural organization ... See more keywords
The Medical Genome Reference Bank: a whole-genome data resource of 4000 healthy elderly individuals. Rationale and cohort design
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-018-0279-z
Abstract: Allele frequency data from human reference populations is of increasing value for the filtering, interpretation, and assignment of pathogenicity to genetic variants. Aged and healthy populations are more likely to be selectively depleted of pathogenic… read more here.
Keywords: healthy elderly; whole genome; elderly individuals; genetics ... See more keywords
β-amyloid pathology and hippocampal atrophy are independently associated with memory function in cognitively healthy elderly
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47638-y
Abstract: The independent effects of different brain pathologies on age-dependent cognitive decline are unclear. We examined this in 300 cognitively unimpaired elderly individuals from the BioFINDER study. Using cognition as outcome we studied the effects of… read more here.
Keywords: cognitively healthy; healthy elderly; associated memory; pathology ... See more keywords
The effects of different frequencies of rhythmic acoustic stimulation on gait stability in healthy elderly individuals: a pilot study
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98953-2
Abstract: The efficacy of rhythmic acoustic stimulation (RAS) to improve gait and balance in healthy elderly individuals is controversial. Our aim was to investigate, through 3D gait analysis, the effect of different types of RAS (fixed… read more here.
Keywords: healthy elderly; pilot study; elderly individuals; gait ... See more keywords
Effects of cognitive interventions with video games on cognition in healthy elderly people: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos de Neuro-Psiquiatria"
DOI: 10.1055/s-0043-1764413
Abstract: Abstract Background Currently, studies using video games as an intervention to improve cognitive functions in the elderly are on the rise. Objective To investigate and evaluate the effects of cognitive interventions using video games on… read more here.
Keywords: effects cognitive; cognition; video games; review ... See more keywords
Melatonin profile in healthy, elderly subjects - A systematic literature review
Sign Up to like & getrecommendations! Published in 2022 at "Chronobiology International"
DOI: 10.1080/07420528.2021.2016794
Abstract: ABSTRACT Melatonin plays an important role in regulation and maintaining of the circadian rhythm. In the elderly population, an array of disturbances of circadian rhythm and sleep can be observed; however the current knowledge within… read more here.
Keywords: systematic literature; healthy elderly; literature review; melatonin ... See more keywords
Association of size‐fractionated indoor particulate matter and black carbon with heart rate variability in healthy elderly women in Beijing
Sign Up to like & getrecommendations! Published in 2018 at "Indoor Air"
DOI: 10.1111/ina.12449
Abstract: Associations between size-fractionated indoor particulate matter (PM) and black carbon (BC) and heart rate variability (HRV) and heart rate (HR) in elderly women remain unclear. Twenty-nine healthy elderly women were measured for 24-hour HRV/HR indices.… read more here.
Keywords: healthy elderly; fractionated indoor; size fractionated; elderly women ... See more keywords