An Open‐Label, Single‐Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults
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DOI: 10.1002/cpdd.630
Abstract: Amenamevir is an inhibitor of the helicase‐primase enzyme complex developed for the treatment of varicella zoster virus. This mass balance study investigated the absorption, metabolism, and excretion of a single dose (200 mg) of 14C‐labeled… read more here.
Keywords: healthy male; mass balance; amenamevir healthy; balance study ... See more keywords
Pharmacokinetics of intravenous pan-class I phosphatidylinositol 3-kinase (PI3K) inhibitor [14C]copanlisib (BAY 80-6946) in a mass balance study in healthy male volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3383-9
Abstract: PurposeTo determine the pharmacokinetics of radiolabeled copanlisib (BAY 80-6946) in healthy male volunteers and to investigate the disposition and biotransformation of copanlisib.MethodsA single dose of 12 mg copanlisib containing 2.76 MBq [14C]copanlisib was administered as a 1-h… read more here.
Keywords: healthy male; copanlisib; male volunteers; 14c copanlisib ... See more keywords
A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04074-4
Abstract: Purpose Fedratinib, an oral, selective Janus kinase 2 inhibitor with activity against both wild-type and mutant Janus kinase 2, has pH-dependent solubility, with free solubility at pH 1. Concomitant administration of drugs that reduce gastric… read more here.
Keywords: healthy male; study; male subjects; doses pantoprazole ... See more keywords
Are Adverse Events Induced by the Acute Administration of Calcineurin Inhibitor Cyclosporine A Behaviorally Conditioned in Healthy Male Volunteers?
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.09.008
Abstract: PURPOSE The learned immunosuppressive placebo response has been demonstrated in experimental animals, healthy humans, and patients, and is suggested as a therapy for improving immunopharmacologic treatment. It remains unclear, however, whether potential adverse events induced… read more here.
Keywords: healthy male; events induced; behaviorally conditioned; calcineurin inhibitor ... See more keywords
An induced pluripotent stem cells line (ZZUNEUi022-A) derived from urine cells of healthy male human.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102191
Abstract: Urine cells (or renal tubular cells) can be isolated from human urine samples efficiently. This noninvasive and cost-effective method to collect biological sample provide us favorable access to donor cells from human. In the present… read more here.
Keywords: healthy male; zzuneui022; urine cells; pluripotent stem ... See more keywords
Pharmacokinetics and Pharmacodynamics of Tofogliflozin (a Selective SGLT2 Inhibitor) in Healthy Male Subjects.
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DOI: 10.1055/s-0043-104779
Abstract: Tofogliflozin is a selective oral inhibitor of sodium-glucose co-transporter 2 for treatment of type 2 diabetes mellitus. The pharmacokinetics, pharmacodynamics, and safety of tofogliflozin were investigated in healthy male subjects. Three studies were conducted: single-ascending… read more here.
Keywords: healthy male; inhibitor; tofogliflozin; male subjects ... See more keywords
Changes in hematological indices and lymphocyte subsets in response to whole blood donation in healthy male donors
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2017.1286520
Abstract: Abstract Whole blood donation has immunomodulatory effects, and most of these have been observed at short intervals following blood donation. This study aimed to investigate the impact of whole blood donation on lymphocyte subsets over… read more here.
Keywords: healthy male; donation; lymphocyte subsets; blood donation ... See more keywords
An ulcerative nodule on the forearm of a healthy male farmer
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Dermatology"
DOI: 10.1111/ijd.15062
Abstract: A 41-year-old healthy male presented with an erythematous ulcerative nodule on the left forearm that had been rapidly growing for three weeks (Fig. 1a). He had no pertinent past medical history and denied a history… read more here.
Keywords: healthy male; farmer; nodule forearm; ulcerative nodule ... See more keywords
Subacute knee pain and swelling in a healthy male: a case of Brodie’s abscess
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DOI: 10.1136/bcr-2018-227926
Abstract: Osteomyelitis is an inflammatory process of the bone caused by an infection. The key to successful management is early recognition and treatment, as complications can arise if interventions are not done in a timely manner.… read more here.
Keywords: knee pain; healthy male; subacute knee; case ... See more keywords
Colonic Malakoplakia: A Rare Finding in a Healthy Male
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DOI: 10.1159/000492208
Abstract: Malakoplakia is a rare chronic granulomatous disease that may affect many organs, including the lung, brain, adrenal glands, pancreas, bone, and the genitourinary tract. The gastrointestinal tract is the most common site of involvement outside… read more here.
Keywords: healthy male; finding healthy; colonic malakoplakia; malakoplakia rare ... See more keywords
KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-017-0715-0
Abstract: BackgroundMitochondrial disorders are a clinically, biochemically and genetically heterogeneous group of multi-system diseases, with an unmet medical need for treatment. KH176 is an orally bio-available small molecule under development for the treatment of mitochondrial(−related) diseases.… read more here.
Keywords: healthy male; clinical trial; trial; male volunteers ... See more keywords