Sex-specific bone and muscular morphological features in ischiofemoral impingement: a three-Dimensional study.
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DOI: 10.1002/ca.24036
Abstract: INTRODUCTION The study aimed to investigate how hip bone and muscular morphology features differ between ischiofemoral impingement (IFI) patients and healthy subjects among males and females. MATERIALS AND METHODS Three-dimensional models were reconstructed based on… read more here.
Keywords: ischiofemoral impingement; ifi patients; bone; patients healthy ... See more keywords
Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open‐Label, 1‐Sequence, Crossover Studies
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DOI: 10.1002/cpdd.1076
Abstract: Roxadustat inhibits breast cancer resistance protein and organic anion transporting polypeptide 1B1, which can affect coadministered statin concentrations. Three open‐label, 1‐sequence crossover phase 1 studies in healthy subjects were conducted to assess effects from steady‐state… read more here.
Keywords: roxadustat; label sequence; sequence crossover; atorvastatin ... See more keywords
Effect of Futibatinib on Cardiac Repolarization: Results of a Randomized, Controlled, Double‐Blind, QT/QTc, Phase 1 Study in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1195
Abstract: Futibatinib, a fibroblast growth factor receptor (FGFR) 1–4 inhibitor, is being investigated for FGFR‐aberrant tumors. A 4‐period, crossover, phase 1 thorough QT/QTc study compared effects on Fridericia heart rate–corrected QT (QTcF) interval of single doses… read more here.
Keywords: effect futibatinib; qtc; phase; futibatinib ... See more keywords
Biosimilarity Assessment of the Biosimilar Teriparatide Candidate and the Reference Drug in Healthy Subjects
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DOI: 10.1002/cpdd.1221
Abstract: SAL001, a recombinant form of parathyroid hormone, is a biosimilar drug to teriparatide and is planned to be used in osteoporosis treatment. A single‐dose, randomized, open‐label, 2‐way crossover trial was conducted in healthy subjects to… read more here.
Keywords: reference drug; reference; concentration; teriparatide ... See more keywords
The Pharmacokinetics and Bioequivalence of Desvenlafaxine Succinate in Chinese Healthy Subjects Under Fasting and Fed States.
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DOI: 10.1002/cpdd.1272
Abstract: Desvenlafaxine succinate is a selective serotonin-norepinephrine reuptake inhibitor for the treatment of major depressive disorder. The pharmacokinetic profile of desvenlafaxine succinate at the clinically recommended dose of 50 mg in Chinese healthy subjects has been reported… read more here.
Keywords: fasting fed; desvenlafaxine succinate; pharmacokinetics bioequivalence; chinese healthy ... See more keywords
Pharmacokinetic Interactions Between Isavuconazole and the Drug Transporter Substrates Atorvastatin, Digoxin, Metformin, and Methotrexate in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.280
Abstract: This article summarizes 4 phase 1 trials that explored interactions between the novel, triazole antifungal isavuconazole and substrates of the drug transporters breast cancer resistance protein (BCRP), multidrug and toxin extrusion protein‐1 (MATE1), organic anion… read more here.
Keywords: digoxin; atorvastatin digoxin; digoxin metformin; drug ... See more keywords
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects
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DOI: 10.1002/cpdd.648
Abstract: Plazomicin is an aminoglycoside that was engineered to overcome aminoglycoside‐modifying enzymes, which are the most common aminoglycoside resistance mechanism in Enterobacteriaceae. Because plazomicin is predominantly eliminated via renal pathways, an in vitro study was conducted… read more here.
Keywords: plasma concentration; metformin; time; healthy subjects ... See more keywords
Thorough QTc Evaluation and the Safety of Supratherapeutic Doses of Odanacatib in Healthy Subjects
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DOI: 10.1002/cpdd.698
Abstract: Assessing risk for QTc interval prolongation in a thorough QTc study is a standard recommendation when evaluating new chemical entities. As part of the clinical development program for odanacatib, an oral selective inhibitor of cathepsin… read more here.
Keywords: safety; qtc evaluation; study; thorough qtc ... See more keywords
Revefenacin, a Long‐Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo‐ and Positive‐Controlled Thorough QT Study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.732
Abstract: Revefenacin is a novel once‐daily, lung‐selective, long‐acting muscarinic antagonist developed as a nebulized inhalation solution for the maintenance treatment of chronic obstructive pulmonary disease. In a randomized, 4‐way crossover study, healthy subjects received a single… read more here.
Keywords: muscarinic antagonist; long acting; prolong interval; healthy subjects ... See more keywords
Application of a Backpropagation Artificial Neural Network in Predicting Plasma Concentration and Pharmacokinetic Parameters of Oral Single‐Dose Rosuvastatin in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.809
Abstract: A backpropagation artificial neural network (BPANN) model was established for the prediction of the plasma concentration and pharmacokinetic parameters of rosuvastatin (RVST) in healthy subjects. The data (demographic characteristics and results of clinical laboratory tests)… read more here.
Keywords: plasma concentration; concentration pharmacokinetic; model; healthy subjects ... See more keywords
Safety, Tolerability, and Pharmacokinetics of Mevidalen (LY3154207), a Centrally Acting Dopamine D1 Receptor‐Positive Allosteric Modulator (D1PAM), in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.874
Abstract: Activation of the brain dopamine D1 receptor has attracted attention because of its promising role in neuropsychiatric diseases. Although efforts to develop D1 agonists have been challenging, a positive allosteric modulator (PAM), represents an attractive… read more here.
Keywords: allosteric modulator; mevidalen ly3154207; healthy subjects; dopamine receptor ... See more keywords