Multiscale Anisotropic Scaffold Integrating 3D Printing and Electrospinning Techniques as a Heart-on-a-chip Platform for Evaluating Drug-induced Cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300719
Abstract: Cardiac safety assessments are significant in drug discovery, as drug-induced cardiotoxicity is the primary cause of drug attrition. Despite heart-on-a-chip technology having become an increasingly popular tool for evaluating drug-induced cardiotoxicity, its development remains a… read more here.
Keywords: drug induced; induced cardiotoxicity; cardiotoxicity; drug ... See more keywords
Electroconductive and Anisotropic Structural Color Hydrogels for Visual Heart-on-a-Chip Construction.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105777
Abstract: Heart-on-a-chip plays an important role in revealing the biological mechanism and developing new drugs for cardiomyopathy. Tremendous efforts have been devoted to developing heart-on-a-chip systems featuring simplified fabrication, accurate imitation and microphysiological visuality. In this… read more here.
Keywords: heart chip; color; structural color; electroconductive anisotropic ... See more keywords
Assessing the influence of perfusion on cardiac microtissue maturation: A heart‐on‐chip platform embedding peristaltic pump capabilities
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27836
Abstract: Heart‐on‐chip is an unprecedented technology for recapitulating key biochemical and biophysical cues in cardiac pathophysiology. Several designs have been proposed to improve its ability to mimic the native tissue and establish it as a reliable… read more here.
Keywords: heart; heart chip; platform; maturation ... See more keywords
Electromechanical Stimulation of 3D Cardiac Microtissues in a Heart-on-Chip Model.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1693-2_9
Abstract: Modeling human cardiac tissues in vitro is essential to elucidate the biological mechanisms related to the heart physiopathology, possibly paving the way for new treatments. Organs-on-chips have emerged as innovative tools able to recreate tissue-specific… read more here.
Keywords: heart chip; heart; chip model; electromechanical stimulation ... See more keywords
Sensors in heart-on-a-chip: A review on recent progress.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2020.121269
Abstract: Drug-induced cardiotoxicity is a major problem in drug discovery. Many approaches to efficient drug screening have been developed, including animal testing in vivo and cell testing in vitro. However, due to intrinsic difference between species,… read more here.
Keywords: chip review; heart; heart chip; review ... See more keywords
Automated fabrication of photopatterned gelatin hydrogels for organ-on-chips applications.
Sign Up to like & getrecommendations! Published in 2018 at "Biofabrication"
DOI: 10.1088/1758-5090/aa96de
Abstract: Organ-on-chip platforms aim to improve preclinical models for organ-level responses to novel drug compounds. Heart-on-a-chip assays in particular require tissue engineering techniques that rely on labor-intensive photolithographic fabrication or resolution-limited 3D printing of micropatterned substrates,… read more here.
Keywords: organ chips; hydrogels organ; fabrication; heart chip ... See more keywords
Timely delivery of cardiac mmRNAs in microfluidics enhances cardiogenic programming of human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.871867
Abstract: In the last two decades lab-on-chip models, specifically heart-on-chip, have been developed as promising technologies for recapitulating physiological environments suitable for studies of drug and environmental effects on either human physiological or patho-physiological conditions. Most… read more here.
Keywords: pluripotent stem; human pluripotent; chip; stem cells ... See more keywords
Tailoring cardiac environment in microphysiological systems: an outlook on current and perspective heart-on-chip platforms
Sign Up to like & getrecommendations! Published in 2017 at "Future Science OA"
DOI: 10.4155/fsoa-2017-0024
Abstract: With cardiovascular diseases representing a leading cause of death worldwide, several biological aspects of heart physiology and pathology remain open and therapeutic needs widely unmet. The attention of biomedical research has been directed toward the… read more here.
Keywords: heart; outlook; heart chip; cardiac environment ... See more keywords