Inspiration from heart development: Biomimetic development of functional human cardiac organoids.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.07.021
Abstract: Recent progress in human organoids has provided 3D tissue systems to model human development, diseases, as well as develop cell delivery systems for regenerative therapies. While direct differentiation of human embryoid bodies holds great promise… read more here.
Keywords: cardiac organoids; heart development; human cardiac; cell ... See more keywords
microRNAs and cardiac stem cells in heart development and disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.05.032
Abstract: Cumulative evidence has proven that proliferation, differentiation and migration of cardiac stem cells (CSCs) dominate early heart development and contribute to the later occurrence of heart disease. Among other mechanisms, microRNAs work as the 'fine-tuning'… read more here.
Keywords: heart; cardiac stem; disease; heart development ... See more keywords
Identification of differential microRNAs and messenger RNAs resulting from ASXL transcriptional regulator 3 knockdown during during heart development
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2062525
Abstract: ABSTRACT Congenital heart disease (CHD) is the most common birth defect. Although ASXL transcriptional regulator 3 (ASXL3) has been reported to cause hereditary CHD, ASXL3-mediated mechanisms in heart development remain unclear. In this study, we… read more here.
Keywords: heart development; asxl transcriptional; heart; asxl3 knockdown ... See more keywords
P313ADGRL2 is an essential surface molecule for cardiac lineage specification and heart development
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz747.0148
Abstract: Specific surface markers that enable monitoring of cell subsets would be valuable for establishing the conditions under which pluripotent stem cells (PSCs) differentiate into cardiac progenitor cells (CPCs) and cardiomyocytes (CMCs). To verify whether a… read more here.
Keywords: heart; adgrl2; heart development; expression ... See more keywords
RBFOX2 is required for establishing RNA regulatory networks essential for heart development
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac055
Abstract: Abstract Human genetic studies identified a strong association between loss of function mutations in RBFOX2 and hypoplastic left heart syndrome (HLHS). There are currently no Rbfox2 mouse models that recapitulate HLHS. Therefore, it is still… read more here.
Keywords: heart development; rbfox2; cell ecm; heart ... See more keywords
The G Protein-Coupled Receptor Latrophilin-2, A Marker for Heart Development, Induces Myocardial Repair After Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szab015
Abstract: Abstract Discovering cell–surface markers based on a comprehensive understanding of development is utilized to isolate a particular cell type with high purity for therapeutic purposes. Given that latrophilin-2 (Lphn2) substantially contributes to cardiac differentiation, we… read more here.
Keywords: cell; heart development; lphn2 cells; heart ... See more keywords
Epicardium in Heart Development.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a037192
Abstract: The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair. The heterogenous cell population that… read more here.
Keywords: epicardium; heart development; biology; development ... See more keywords
The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16602
Abstract: As a common air pollutant, formaldehyde is widely present in nature, industrial production and consumer products. Endogenous formaldehyde is mainly produced through the oxidative deamination of methylamine catalysed by semicarbazide‐sensitive amine oxidase (SSAO) and is… read more here.
Keywords: heart; disease; formaldehyde cardiovascular; heart development ... See more keywords
Optical coherence tomography for in vivo imaging of endocardial to mesenchymal transition during avian heart development.
Sign Up to like & getrecommendations! Published in 2019 at "Biomedical optics express"
DOI: 10.1364/boe.10.005989
Abstract: The endocardial to mesenchymal transition (EndMT) that occurs in endocardial cushions during heart development is critical for proper heart septation and formation of the heart's valves. In EndMT, cells delaminate from the endocardium and migrate… read more here.
Keywords: optical coherence; mesenchymal transition; heart; endocardial mesenchymal ... See more keywords
Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0212992
Abstract: The homeodomain transcription factor NKX2-5 is known to be essential for both normal heart development and for heart function. But little is yet known about the identities of its downstream effectors or their function during… read more here.
Keywords: function; heart development; heart; furin transcriptional ... See more keywords
EZH2 controls epicardial cell migration during heart development
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201765
Abstract: EZH2 influences epicardial cell migration into the myocardium via TIMP3-dependent fine tuning of basement membrane degradation, which leads to cardiac malformations and embryonic lethality. Enhancer of zeste homolog 2 (EZH2) is an important transcriptional regulator… read more here.
Keywords: development; cell migration; heart development; epicardial cell ... See more keywords