Single-cell morphometrics reveals T-box gene-dependent patterns of epithelial tension in the Second Heart field
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53612-8
Abstract: The vertebrate heart tube extends by progressive addition of epithelial second heart field (SHF) progenitor cells from the dorsal pericardial wall. The interplay between epithelial mechanics and genetic mechanisms during SHF deployment is unknown. Here,… read more here.
Keywords: heart; cell; morphometrics; heart field ... See more keywords
The pericardium forms as a distinct structure during heart formation
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63599-5
Abstract: The heart is formed from diverse cell lineages that assemble into a functional unit, including the pericardium, a mesothelial sac that supports movement, homeostasis, and immune responses. However, its developmental origins remain unresolved. Here, we… read more here.
Keywords: heart; pericardium; pericardium forms; cell ... See more keywords
Isolation and characterization of hESC-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profiles.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab102
Abstract: AIMS We prospectively isolate and characterize first and second heart field- and nodal-like cardiomyocytes using a double reporter line from human embryonic stem cells. Our double reporter line utilizes two important transcription factors in cardiac… read more here.
Keywords: heart; heart field; specific cardiomyocytes; field specific ... See more keywords
Tbx1 regulates extracellular matrix-cell interactions in the second heart field.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz058
Abstract: Tbx1, the major candidate gene for DiGeorge or 22q11.2 deletion syndrome, is required for efficient incorporation of cardiac progenitors of the second heart field (SHF) into the heart. However, the mechanisms by which TBX1 regulates… read more here.
Keywords: tbx1; heart; tbx1 regulates; extracellular matrix ... See more keywords
HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008165
Abstract: Coordinated transcriptional and epigenetic mechanisms that direct development of the later differentiating second heart field (SHF) progenitors remain largely unknown. Here, we show that a novel zebrafish histone deacetylase 1 (hdac1) mutant allele cardiac really… read more here.
Keywords: second heart; heart field; hdac1; retinoic acid ... See more keywords
Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008782
Abstract: The planar cell polarity pathway is required for heart development and whilst the functions of most pathway members are known, the roles of the jnk genes in cardiac morphogenesis remain unknown as mouse mutants exhibit… read more here.
Keywords: jnk1a; heart; heart field; hand2 expression ... See more keywords